TY - JOUR
T1 - Class II HLA alleles and hepatitis B virus persistence in African Americans
AU - Thio, Chloe L.
AU - Carrington, Mary
AU - Marti, Darlene
AU - O'Brien, Stephen J.
AU - Vlahov, David
AU - Nelson, Kenrad Edwin
AU - Astemborski, Jacquie
AU - Thomas, David L.
N1 - Funding Information:
Received 19 August 1998; revised 24 November 1998. Informed consent was obtained from all patients and was approved by the Institutional Review Board at Johns Hopkins University. Financial support: NIH (grants DA-04334, DA-05911, DA-8009, and AI-40035; contract NO1-CO-56000). Reprints or correspondence: Dr. David L. Thomas, Division of Infectious Diseases, Johns Hopkins University, 1147 Ross Research Building, 720 Rutland Ave., Baltimore, MD 21205 (dt@jhu.edu).
PY - 1999
Y1 - 1999
N2 - Persistence of hepatitis B virus (HBV) infection is likely due to the interplay of the virus and host immune response. Given its critical role in antigen presentation, allelic differences in the HLA complex may affect HBV persistence. In a prospectively followed African American cohort, molecular class I and class II HLA typing was done on 31 subjects with persistent HBV infection and 60 controls who cleared the infection. HBV persistence was significantly associated with two class II alleles, DQA1*0501 (odds ratio [OR], 2.6; P= .05) and DQB1*0301 (OR, 3.9; P = .01), the two-locus haplotype consisting of these same two alleles (OR, 3; P = .005) and the three-locus haplotype, DQA1*0501, DQB1*0301, and DRB1 * 1102 (OR, 10.7; P = .01). In addition, HBV Persistence was associated with class II allelic homozygosity. Several class I associations with persistence were also noted but were not statistically significant after correction for multiple comparisons. These results underscore the importance of the class II-mediated immune response in recovery from HBV infection.
AB - Persistence of hepatitis B virus (HBV) infection is likely due to the interplay of the virus and host immune response. Given its critical role in antigen presentation, allelic differences in the HLA complex may affect HBV persistence. In a prospectively followed African American cohort, molecular class I and class II HLA typing was done on 31 subjects with persistent HBV infection and 60 controls who cleared the infection. HBV persistence was significantly associated with two class II alleles, DQA1*0501 (odds ratio [OR], 2.6; P= .05) and DQB1*0301 (OR, 3.9; P = .01), the two-locus haplotype consisting of these same two alleles (OR, 3; P = .005) and the three-locus haplotype, DQA1*0501, DQB1*0301, and DRB1 * 1102 (OR, 10.7; P = .01). In addition, HBV Persistence was associated with class II allelic homozygosity. Several class I associations with persistence were also noted but were not statistically significant after correction for multiple comparisons. These results underscore the importance of the class II-mediated immune response in recovery from HBV infection.
UR - http://www.scopus.com/inward/record.url?scp=0001624087&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0001624087&partnerID=8YFLogxK
U2 - 10.1086/314684
DO - 10.1086/314684
M3 - Article
C2 - 10068598
AN - SCOPUS:0001624087
SN - 0022-1899
VL - 179
SP - 1004
EP - 1006
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -