@inbook{de69459a2e0049d4ac3dad7430ce0d9a,
title = "Class I PI3K Biology",
abstract = "This chapter is an introduction to phosphoinositide 3-kinases (PI3K), with class I PI3Ks as the central focus. First, the various PI3K isoforms in class I are presented with emphasis on their overall structure, subunits, subunit constitutive domains, domain-domain interactions, and functional relevance. This structural analysis is followed by a comprehensive history of seminal investigations into PI3K activity. Next, we highlight the divergent roles of the isoforms: PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ. This section details signaling pathways in which these PI3K isoforms are involved, including the key upstream regulators of PI3K activity and some downstream cellular effects. Nodes of the PI3K pathway are also presented. Inhibitors of some isoforms are discussed to give an overview of the basis of some immunotherapies that are being used to target cell signaling. Finally, the chapter ends with a discussion of the dysregulation of PI3Ks in diseases including APDS, asthma, arthritis, and oncogenic mutations.",
keywords = "APDS, Arthritis, Asthma, B-cell signaling, Chronic inflammation, Class I PI3Ks, Oncogenic mutation, PI3K, Phosphoinositide-3-kinase, RTK signaling, Ras signaling, T-cell signaling, p101, p110β, p110γ, p110δ, p84, pl10α",
author = "Aytenfisu, {Tihitina Y.} and Campbell, {Hannah M.} and Mayukh Chakrabarti and Amzel, {L. Mario} and Gabelli, {Sandra B.}",
note = "Funding Information: Acknowledgements T.Y.A. is a PURA scholar. H.M.C. is a Sr. Alma Nicholas Science Year experience fellow. This work was partially funded by the financial support of U.S. Department of Defense, DOD CDMRP BC151831 (S.B.G.). Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.",
year = "2022",
doi = "10.1007/978-3-031-06566-8_1",
language = "English (US)",
series = "Current Topics in Microbiology and Immunology",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "3--49",
booktitle = "Current Topics in Microbiology and Immunology",
address = "Germany",
}