Class i MHC molecules as probes of membrane patchiness: From biophysical measurements to modulation of immune responses

Research output: Contribution to journalArticle

Abstract

Here I summarize decades of work using the biophysics of class I MHC molecules to probe the patchiness and heterogeneity of cell surfaces. This program began as a study of membranes generally. MHC molecules were a convenient probe. However, in recent years, it has become clear that the lateral distribution, clustering, of class I MHC molecules in the membrane affects their recognition by effector CTL. This offers the possibility of enhancing or reducing T-cell recognition of targets by altering the clustering of their membrane proteins.

Original languageEnglish (US)
Pages (from-to)265-272
Number of pages8
JournalImmunologic Research
Volume47
Issue number1-3
DOIs
StatePublished - Jul 2010

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Cluster Analysis
Biophysics
Membranes
Membrane Proteins
T-Lymphocytes

Keywords

  • Antigen recognition
  • Class I MHC
  • Effector T cells
  • Lateral diffusion
  • Membranes

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

Cite this

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