Abstract
Here I summarize decades of work using the biophysics of class I MHC molecules to probe the patchiness and heterogeneity of cell surfaces. This program began as a study of membranes generally. MHC molecules were a convenient probe. However, in recent years, it has become clear that the lateral distribution, clustering, of class I MHC molecules in the membrane affects their recognition by effector CTL. This offers the possibility of enhancing or reducing T-cell recognition of targets by altering the clustering of their membrane proteins.
Original language | English (US) |
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Pages (from-to) | 265-272 |
Number of pages | 8 |
Journal | Immunologic Research |
Volume | 47 |
Issue number | 1-3 |
DOIs | |
State | Published - Jul 2010 |
Keywords
- Antigen recognition
- Class I MHC
- Effector T cells
- Lateral diffusion
- Membranes
ASJC Scopus subject areas
- Immunology