Clarithromycin is inactive against Mycobacterium tuberculosis

C. Truffot-Pernot, N. Lounis, J. H. Grosset, B. Ji

Research output: Contribution to journalArticle

Abstract

When 10% oleic acid-albumin-dextrose-catalase-enriched Mueller-Hinton agar medium was employed, the MICs of clarithromycin (CLARI) at which 50 and 90% of 12 strains of Mycobacterium tuberculosis were inhibited were 64 and >128 μg/ml, respectively, which are significantly greater than the achievable peak CLARI concentrations in serum and in lung tissue in humans. In two different mouse experiments, 4 to 6 weeks of treatment with CLARI at 200 mg/kg of body weight six times weekly produced neither bactericidal nor bacteriostatic effects against M. tuberculosis. Therefore, we conclude that CLARI as a single drug is inactive against M. tuberculosis.

Original languageEnglish (US)
Pages (from-to)2827-2828
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume39
Issue number12
StatePublished - 1995
Externally publishedYes

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Clarithromycin
Mycobacterium tuberculosis
Oleic Acid
Catalase
Agar
Albumins
Body Weight
Glucose
Lung
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Truffot-Pernot, C., Lounis, N., Grosset, J. H., & Ji, B. (1995). Clarithromycin is inactive against Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy, 39(12), 2827-2828.

Clarithromycin is inactive against Mycobacterium tuberculosis. / Truffot-Pernot, C.; Lounis, N.; Grosset, J. H.; Ji, B.

In: Antimicrobial Agents and Chemotherapy, Vol. 39, No. 12, 1995, p. 2827-2828.

Research output: Contribution to journalArticle

Truffot-Pernot, C, Lounis, N, Grosset, JH & Ji, B 1995, 'Clarithromycin is inactive against Mycobacterium tuberculosis', Antimicrobial Agents and Chemotherapy, vol. 39, no. 12, pp. 2827-2828.
Truffot-Pernot C, Lounis N, Grosset JH, Ji B. Clarithromycin is inactive against Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 1995;39(12):2827-2828.
Truffot-Pernot, C. ; Lounis, N. ; Grosset, J. H. ; Ji, B. / Clarithromycin is inactive against Mycobacterium tuberculosis. In: Antimicrobial Agents and Chemotherapy. 1995 ; Vol. 39, No. 12. pp. 2827-2828.
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