Clara cell damage and inhibition of pulmonary mixed-function oxidase activity by naphthalene

Samuel S. Tong, Yoichiro Hirokata, Michael A. Trush, Edward G. Mimnaugh, Erika Ginsburg, Michael C. Lowe, Theodore E. Gram

Research output: Contribution to journalArticlepeer-review

Abstract

The administration of naphthalene has been shown previously to elicit selective damage and necrosis of the Clara cells of mouse lung. Under identical conditions, we have found naphthalene administration to produce selective depression of pulmonary monooxygenase activities without accompanying changes in hepatic monooxygenases. Similarly, morphologic studies revealed dose-dependent alterations of Clara cells lining pulmonary bronchioles but no remarkable changes in livers of the same animals. The underlying biochemical basis for these organ-specific effects of naphthalene is presently obscure.

Original languageEnglish (US)
Pages (from-to)944-950
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume100
Issue number3
DOIs
StatePublished - Jun 16 1981

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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