The administration of naphthalene has been shown previously to elicit selective damage and necrosis of the Clara cells of mouse lung. Under identical conditions, we have found naphthalene administration to produce selective depression of pulmonary monooxygenase activities without accompanying changes in hepatic monooxygenases. Similarly, morphologic studies revealed dose-dependent alterations of Clara cells lining pulmonary bronchioles but no remarkable changes in livers of the same animals. The underlying biochemical basis for these organ-specific effects of naphthalene is presently obscure.
|Original language||English (US)|
|Number of pages||7|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Jun 16 1981|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology