TY - JOUR
T1 - CKiD (CKD in Children) prospective cohort study
T2 - A review of current findings
AU - Wong, Cynthia J.
AU - Moxey-Mims, Marva
AU - Jerry-Fluker, Judith
AU - Warady, Bradley A.
AU - Furth, Susan L.
N1 - Funding Information:
Support: The CKiD Study is supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Neurological Disorders and Stroke , National Institute of Child Health and Human Development , and National Heart, Lung and Blood Institute . Study sponsors had a role in the study design; collection, analysis, and interpretation of data; writing this review; and the decision to submit the review for publication.
PY - 2012/12
Y1 - 2012/12
N2 - Chronic kidney disease (CKD) is a life-long condition associated with substantial morbidity and premature death due to complications from a progressive decrease in kidney function. The incidence and prevalence of all stages of CKD in children continues to increase worldwide. Between 2000 and 2008, the kidney replacement therapy incidence rate in those aged 0-19 years increased 5.9% to 15 per million population, highlighting the importance of CKD research in children. Many comorbid conditions seen in adults with CKD, including cardiovascular disease and cognitive impairment, also are highly prevalent in children, implicitly demonstrating the crucial need for initiating therapy early to improve health outcomes in children with CKD. The CKiD (Chronic Kidney Disease in Children) Study is a prospective cohort study of 586 children aged 1-16 years with an estimated glomerular filtration rate of 30-90 mL/min/1.73 m2. Since its inception, CKiD has identified risk factors for CKD progression and cardiovascular disease in children with CKD and highlighted the effects of CKD on outcomes unique to children, including neurocognitive development and growth. This review summarizes the findings to date, illustrating the spectrum of CKD-associated complications in children and emphasizing areas requiring further investigation. Taken in sum, these elements stress that initiating treatment at an early age is essential for reducing long-term morbidity and mortality in children with CKD.
AB - Chronic kidney disease (CKD) is a life-long condition associated with substantial morbidity and premature death due to complications from a progressive decrease in kidney function. The incidence and prevalence of all stages of CKD in children continues to increase worldwide. Between 2000 and 2008, the kidney replacement therapy incidence rate in those aged 0-19 years increased 5.9% to 15 per million population, highlighting the importance of CKD research in children. Many comorbid conditions seen in adults with CKD, including cardiovascular disease and cognitive impairment, also are highly prevalent in children, implicitly demonstrating the crucial need for initiating therapy early to improve health outcomes in children with CKD. The CKiD (Chronic Kidney Disease in Children) Study is a prospective cohort study of 586 children aged 1-16 years with an estimated glomerular filtration rate of 30-90 mL/min/1.73 m2. Since its inception, CKiD has identified risk factors for CKD progression and cardiovascular disease in children with CKD and highlighted the effects of CKD on outcomes unique to children, including neurocognitive development and growth. This review summarizes the findings to date, illustrating the spectrum of CKD-associated complications in children and emphasizing areas requiring further investigation. Taken in sum, these elements stress that initiating treatment at an early age is essential for reducing long-term morbidity and mortality in children with CKD.
KW - CKD progression
KW - Chronic kidney disease
KW - cardiovascular disease
KW - children
KW - growth
KW - neurodevelopment
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U2 - 10.1053/j.ajkd.2012.07.018
DO - 10.1053/j.ajkd.2012.07.018
M3 - Review article
C2 - 23022429
AN - SCOPUS:84868695490
SN - 0272-6386
VL - 60
SP - 1002
EP - 1011
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 6
ER -