Cisplatin therapy in recurrent childhood brain tumors

A. B. Khan, B. J. D'Souza, M. D. Wharam, L. A. Champion, L. F. Sinks, S. Y. Woo, D. C. McCullough, B. G. Leventhal

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


Twenty-two patients with brain tumors were initially treated with surgery, radiation therapy, and/or adjuvant chemotherapy. Histologic diagnosis included 11 gliomas, seven ependymomas, one dysgerminoma, one teratocarcinoma, one pinealoma, and one small cell tumor. At recurrence, documented on computerized tomographic scan, cisplatin (60 mg/m 2/day iv x 2) was given every 3-4 weeks. Seventeen patients received two or more courses and were considered to be evaluable for response. Response parameters included change in the size of tumor on computerized tomographic scan and/or in clinical findings. Four patients had complete response, five had partial response, four had stable disease, and four had disease progression. Toxic effects were manageable. The number of patients with grade 3-4 toxic reactions, by category, were: thrombocytic, ten; leukocytic, four; renal, five; metabolic, four; gastrointestinal, none; and neurologic, seven. Two of the 14 patients tested had grade 3.4 ototoxicity. Acute fluid retention with decreased serum electrolytes and serious but reversible changes in the mental status, which were experienced in earlier patients, decreased in severity with increasing experience of the investigator. In summary, cisplatin appears to be active in a spectrum of brain tumors and should be studied further for therapeutic efficacy.

Original languageEnglish (US)
Pages (from-to)2013-2020
Number of pages8
JournalCancer treatment reports
Issue number12
StatePublished - 1982

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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