Cisplatin in recurrent pediatric brain tumors A pog phase II study a pediatric oncology group study

Charles L. Sexauer, Atiya Khan, Peter C. Burger, Jeffrey P. Krischer, Jan Van Eys, Tribhawan Vats, Abdelsalam H. Ragab

Research output: Contribution to journalArticlepeer-review

Abstract

Forty‐six evaluable pediatric patients with primary recurrent brain tumors resistant to standard therapy were treated with cisplatin, 60 mg/m2/day, X2 days every 3 to 4 weeks, to study the efficacy and toxicity of this drug. Complete and partial responses, documented by computed tomography (CT) scan, were demonstrated in 4 of 10 patients with medulloblastoma and 3 of 15 patients with ependymoma. No activity was documented in astrocytic tumors. Dose limiting major toxicities were renal and auditory. It is recommended that the new analogues of cisplatin with less toxicity be studied in these tumors.

Original languageEnglish (US)
Pages (from-to)1497-1501
Number of pages5
JournalCancer
Volume56
Issue number7
DOIs
StatePublished - Oct 1 1985

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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