Cisplatin administration following carboplatin desensitization failure in primary peritoneal cancer: A brief report

Daniel P. Greene, James Stuart Ferriss, Amir A. Jazaeri

Research output: Contribution to journalArticle

Abstract

Purpose: Platinum-based therapy is the cornerstone of ovarian cancer treatment. Development of platinum hypersensitivity can limit therapeutic options. In this brief report, we present case of successful cisplatin administration following two unsuccessful carboplatin desensitization attempts, and without the need for pre-treatment steroids. Methods: Retrospective chart review was performed. Results: One case of recurrent primary peritoneal carcinoma previously treated with a carboplatin-based regimen, developed a platinum hypersensitivity. Two attempts at carboplatin desensitization were unsuccessful. Cisplatin was substituted and the patient achieved a complete response to therapy without further hypersensitivity. Conclusions: Platinum-based therapies are vital to the treatment of primary peritoneal and ovarian carcinoma. Protocols that successfully incorporate platinum agents, despite a platinum hypersensitivity, are clinically relevant.

Original languageEnglish (US)
Pages (from-to)265-267
Number of pages3
JournalCancer Chemotherapy and Pharmacology
Volume66
Issue number2
DOIs
StatePublished - Jul 1 2010
Externally publishedYes

Keywords

  • Cisplatin
  • Peritoneal carcinoma
  • Platinum desensitization failure
  • Platinum hypersensitivity

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Cisplatin administration following carboplatin desensitization failure in primary peritoneal cancer: A brief report'. Together they form a unique fingerprint.

  • Cite this