TY - JOUR
T1 - Circulating Vα24+ Vβ11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage
AU - Van Der Vliet, Hans J J
AU - Von Blomberg, B. Mary E
AU - Nishi, Nobusuke
AU - Reijm, Martine
AU - Voskuyl, Alexandre E.
AU - Van Bodegraven, Ad A.
AU - Polman, Chris H.
AU - Rustemeyer, Thomas
AU - Lips, Paul
AU - Van Den Eertwegh, Alfons J M
AU - Giaccone, Giuseppe
AU - Scheper, Rik J.
AU - Pinedo, Herbert M.
PY - 2001
Y1 - 2001
N2 - Natural killer T (NKT) cells have been implicated as playing an important role in regulating immune responses. Defects in the NKT cell population were reported in animal autoimmune disease models and in distinct human autoimmune diseases. Here, we report that circulating Vα24+ Vβ11+ NKT cell numbers are decreased in a broad variety of disorders with (auto)immune-mediated pathology, affecting the skin, bowel, central nervous system, and joints, regardless of disease duration or activity. Remarkably, normal circulating Vα24+ Vβ11+ NKT cell numbers were found in Graves disease and coeliac disease. Since earlier studies noted a rise in NKT cells in myasthenia gravis, the picture emerges in which a defective NKT cell population is associated with autoreactive tissue damage rather than with the propensity to develop autoimmune disease. The present data support the idea that therapies aiming at the in vivo expansion of regulatory NKT cells might help to control immune-mediated damage in autoimmune disease.
AB - Natural killer T (NKT) cells have been implicated as playing an important role in regulating immune responses. Defects in the NKT cell population were reported in animal autoimmune disease models and in distinct human autoimmune diseases. Here, we report that circulating Vα24+ Vβ11+ NKT cell numbers are decreased in a broad variety of disorders with (auto)immune-mediated pathology, affecting the skin, bowel, central nervous system, and joints, regardless of disease duration or activity. Remarkably, normal circulating Vα24+ Vβ11+ NKT cell numbers were found in Graves disease and coeliac disease. Since earlier studies noted a rise in NKT cells in myasthenia gravis, the picture emerges in which a defective NKT cell population is associated with autoreactive tissue damage rather than with the propensity to develop autoimmune disease. The present data support the idea that therapies aiming at the in vivo expansion of regulatory NKT cells might help to control immune-mediated damage in autoimmune disease.
KW - Autoimmune disease
KW - CD1d
KW - Regulatory cells
KW - Vα24 Vβ11 NKT cells
UR - http://www.scopus.com/inward/record.url?scp=0034742480&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034742480&partnerID=8YFLogxK
U2 - 10.1006/clim.2001.5060
DO - 10.1006/clim.2001.5060
M3 - Article
C2 - 11465942
AN - SCOPUS:0034742480
SN - 1521-6616
VL - 100
SP - 144
EP - 148
JO - Clinical Immunology
JF - Clinical Immunology
IS - 2
ER -