Circulating Vα24+ Vβ11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage

Hans J J Van Der Vliet, B. Mary E Von Blomberg, Nobusuke Nishi, Martine Reijm, Alexandre E. Voskuyl, Ad A. Van Bodegraven, Chris H. Polman, Thomas Rustemeyer, Paul Lips, Alfons J M Van Den Eertwegh, Giuseppe Giaccone, Rik J. Scheper, Herbert M. Pinedo

Research output: Contribution to journalArticlepeer-review

Abstract

Natural killer T (NKT) cells have been implicated as playing an important role in regulating immune responses. Defects in the NKT cell population were reported in animal autoimmune disease models and in distinct human autoimmune diseases. Here, we report that circulating Vα24+ Vβ11+ NKT cell numbers are decreased in a broad variety of disorders with (auto)immune-mediated pathology, affecting the skin, bowel, central nervous system, and joints, regardless of disease duration or activity. Remarkably, normal circulating Vα24+ Vβ11+ NKT cell numbers were found in Graves disease and coeliac disease. Since earlier studies noted a rise in NKT cells in myasthenia gravis, the picture emerges in which a defective NKT cell population is associated with autoreactive tissue damage rather than with the propensity to develop autoimmune disease. The present data support the idea that therapies aiming at the in vivo expansion of regulatory NKT cells might help to control immune-mediated damage in autoimmune disease.

Original languageEnglish (US)
Pages (from-to)144-148
Number of pages5
JournalClinical Immunology
Volume100
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Autoimmune disease
  • CD1d
  • Regulatory cells
  • Vα24 Vβ11 NKT cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

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