Circulating tumor cells in pancreatic cancer: A review

Joseph R. Habib, Jun Yu

Research output: Contribution to journalReview articlepeer-review

Abstract

AbstractPancreatic cancer remains one of the deadliest types of cancer with little or no recent evidence of significant improvement in survival. This is, in large part, due to the current unavailability of effective screening or even early detection methods. Circulating tumor cells (CTCs), particularly with the rapidly improving methods for isolation, enrichment, and characterization methods, have emerged as the next best hope to overcome these challenges. This paper reviews the current state-of-the-art of CTC technologies with particular focus on the various isolation and enrichment methods based on liquid biopsy, the current limitations of these technologies and, consequently, the areas of further research and improvements in CTC methods that are needed to translate it to the clinical setting of routine diagnosis, treatment, and management of pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)54-59
Number of pages6
JournalJournal of Pancreatology
Volume2
Issue number2
DOIs
StatePublished - Jun 2019

Keywords

  • Circulating tumor cells
  • Pancreatic cancer
  • Translational medicine

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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