Circulating tumor cells are associated with poor overall survival in patients with cholangiocarcinoma

Ju Dong Yang, Michael B. Campion, Minetta C. Liu, Roongruedee Chaiteerakij, Nasra H. Giama, Hager Ahmed Mohammed, Xiaodan Zhang, Chunling Hu, Victoria L. Campion, Jin Jen, Sudhakar K. Venkatesh, Kevin C. Halling, Benjamin R. Kipp, Lewis R. Roberts

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Abstract

Circulating tumor cells (CTCs) in blood are associated with poor survival of patients with breast, prostate, or colon cancer. We hypothesized that CTCs are associated with poor survival of patients with cholangiocarcinoma (CCA). Eighty-eight patients with CCA were prospectively enrolled at Mayo Clinic Rochester between June 2010 and September 2014. The CellSearch system by Veridex was used for detection of CTCs in peripheral blood. Associations between CTC, patient and tumor characteristics, and survival were examined using the Cox's proportional hazards model. Fifteen patients (17%) were positive for CTC ≥2 and 8 patients (9%) for CTC ≥5. CTCs were associated with tumor extent. CTC ≥2 (hazard ratio [HR]: 2.5; 95% confidence interval [CI]: 1.1-5.4; P=0.02) and CTC ≥5 (HR, 4.1; 95% CI: 1.4-10.8; P=0.01) were both independent predictors of survival. In subgroup analyses, CTC ≥2 (HR, 8.2; 95% CI: 1.8-57.5; P

Original languageEnglish (US)
Pages (from-to)148-158
Number of pages11
JournalHepatology
Volume63
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

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ASJC Scopus subject areas

  • Hepatology

Cite this

Yang, J. D., Campion, M. B., Liu, M. C., Chaiteerakij, R., Giama, N. H., Ahmed Mohammed, H., Zhang, X., Hu, C., Campion, V. L., Jen, J., Venkatesh, S. K., Halling, K. C., Kipp, B. R., & Roberts, L. R. (2016). Circulating tumor cells are associated with poor overall survival in patients with cholangiocarcinoma. Hepatology, 63(1), 148-158. https://doi.org/10.1002/hep.27944