Circulating thrombomodulin levels and clinical correlates in pregnant diabetics

Urania Magriples, Chaur Dong Hsu, Daniel W. Chan, Nancy Nickless, Joshua A. Copel

Research output: Contribution to journalArticlepeer-review

Abstract

The object of this study was to investigate the relationship of thrombomodulin (TM) and glycosylated hemoglobin (HbA1C) in pregnant diabetics and to determine clinical correlates. We performed a prospective cohort study of 53 patients: 25 women with insulin-dependent diabetes (group 1) and 28 with gestational diabetes (group 2). Group 1 underwent monthly determinations of HbA1C and TM. Group 2 underwent determination at 36 weeks of gestation. There was a significant difference in HbA1C between groups 1 and 2 (p = 0.0005), but there was no difference in TM. There was no correlation between TM and HbA1C. TM levels correlated positively with serum creatinine (r: 0.46, p = 0.002), proteinuria (r= 0.48, p = 0.007), and duration of diabetes (r = 0.41, p = 0.042). TM was significantly higher in diabetics of advanced White Classification (p = 0.008). With good control, TM does not appear to be elevated in a diabetic pregnancy. TM may be a marker of endothelial damage that correlates more with duration of diabetes and renal disease than with HbA1C, which reflects short-term control.

Original languageEnglish (US)
Pages (from-to)605-608
Number of pages4
JournalAmerican journal of perinatology
Volume14
Issue number10
DOIs
StatePublished - Nov 1997

Keywords

  • Diabetes mellitus
  • Glycosylated hemoglobin
  • Thrombomodulin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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