TY - JOUR
T1 - Circulating selenium and carboxymethyl-lysine, an advanced glycation endproduct, are independent predictors of anemia in older community-dwelling adults
AU - Roy, Cindy N.
AU - Semba, Richard D.
AU - Sun, Kai
AU - Bandinelli, Stefania
AU - Varadhan, Ravi
AU - Patel, Kushang V.
AU - Guralnik, Jack M.
AU - Ferrucci, Luigi
N1 - Funding Information:
The work was supported by grants R01 AG027012 and R01 AG029148 from the National Institute on Aging , grant ICS110.1/RF97.71 from the Italian Ministry of Health , contracts 263 MD 9164, 263 MD 821336, N.1-AG-1-1, N.1-AG-1-2111, and N01-AG-5-0002 from the National Institute on Aging , and the Intramural Research Program, National Institute on Aging, National Institutes of Health. C. N. R. also was supported by grant RO1 DK082722 from the American Society of Hematology and grant AG021334 from the Research Career Development Core of the Johns Hopkins Older Americans Independence Center . The baseline Invecchiare in Chianti study (1998–2000) was supported as a “targeted project” by grant ICS110.1/RF97.71 from the Italian Ministry of Health and in part by contracts 263 MD 9164 and 263 MD 821336 from the National Institute on Aging.
PY - 2012/7
Y1 - 2012/7
N2 - Objective: To assess whether selenium and carboxymethyl-lysine (CML), two biomarkers of oxidative stress, are independent predictors of anemia in older community-dwelling adults. Methods: Plasma levels of selenium, CML, folate, vitamin B12, and testosterone and markers of iron status and inflammation were measured at baseline in 1036 adults at least 65 y old in the Invecchiare in Chianti Study, a population-based cohort study of aging in Tuscany, Italy, and examined in relation to prevalent anemia and incident anemia over 6 y of follow-up. Results: At enrollment, 11.6% of participants were anemic. Of 472 participants who were non-anemic at enrollment, 72 (15.3%) developed anemia within 6 y of follow-up. At enrollment, plasma CML in the highest quartile (>425 ng/mL) and plasma selenium in the lowest quartile (<66.6 μg/L) predicted incident anemia (hazard ratio 1.67, 95% confidence interval 1.07-2.59, P = 0.02; hazard ratio 1.55, 95% confidence interval 1.01-2.38, P = 0.05, respectively) in a multivariate Cox proportional hazards model that adjusted for age, education, body mass index, cognition, inflammation, red blood cell distribution width, ferritin, vitamin B12, testosterone, and chronic diseases. Conclusion: Elevated plasma CML and low plasma selenium are long-term independent predictors of anemia in older community-dwelling adults. These findings support the idea that oxidative stress contributes to the development of anemia.
AB - Objective: To assess whether selenium and carboxymethyl-lysine (CML), two biomarkers of oxidative stress, are independent predictors of anemia in older community-dwelling adults. Methods: Plasma levels of selenium, CML, folate, vitamin B12, and testosterone and markers of iron status and inflammation were measured at baseline in 1036 adults at least 65 y old in the Invecchiare in Chianti Study, a population-based cohort study of aging in Tuscany, Italy, and examined in relation to prevalent anemia and incident anemia over 6 y of follow-up. Results: At enrollment, 11.6% of participants were anemic. Of 472 participants who were non-anemic at enrollment, 72 (15.3%) developed anemia within 6 y of follow-up. At enrollment, plasma CML in the highest quartile (>425 ng/mL) and plasma selenium in the lowest quartile (<66.6 μg/L) predicted incident anemia (hazard ratio 1.67, 95% confidence interval 1.07-2.59, P = 0.02; hazard ratio 1.55, 95% confidence interval 1.01-2.38, P = 0.05, respectively) in a multivariate Cox proportional hazards model that adjusted for age, education, body mass index, cognition, inflammation, red blood cell distribution width, ferritin, vitamin B12, testosterone, and chronic diseases. Conclusion: Elevated plasma CML and low plasma selenium are long-term independent predictors of anemia in older community-dwelling adults. These findings support the idea that oxidative stress contributes to the development of anemia.
KW - Advanced glycation endproducts
KW - Aging
KW - Anemia
KW - Carboxymethyl-lysine
KW - Oxidative stress
KW - Selenium
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U2 - 10.1016/j.nut.2011.11.005
DO - 10.1016/j.nut.2011.11.005
M3 - Article
C2 - 22325035
AN - SCOPUS:84862184681
SN - 0899-9007
VL - 28
SP - 762
EP - 766
JO - Nutrition
JF - Nutrition
IS - 7-8
ER -