Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling women

Justine Beck, Luigi Ferrucci, Kai Sun, Linda P. Fried, Ravi Varadhan, Jeremy Walston, Jack M. Guralnik, Richard D. Semba

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The objective of this study was to determine whether total serum carotenoids, α-tocopherol, selenium, and obesity were independently associated with oxidized low-density lipoproteins (ox-LDLs) in moderately to severely disabled older women living in the community. Methods: Serum ox-LDLs, carotenoids, α-tocopherol, and selenium were measured in a population-based sample of 543 moderately to severely disabled women ≥65 y in the Women's Health and Aging Study I in Baltimore, Maryland. Results: Total serum carotenoids, smoking, overweight (body mass index 25-29.9 kg/m2), and obesity (body mass index ≥30 mg/kg2) were significantly associated with the ox-LDL/LDL cholesterol ratio after adjusting for age, C-reactive protein, and chronic diseases. α-Tocopherol and selenium were not significantly associated with the ox-LDL/LDL cholesterol ratio. Conclusion: Older women who are overweight or obese or who have low total serum carotenoids are more likely to have higher lipoprotein oxidation. Weight reduction in overweight/obese women and increased intake of carotenoid-rich foods may potentially reduce lipoprotein oxidation.

Original languageEnglish (US)
Pages (from-to)964-968
Number of pages5
JournalNutrition
Volume24
Issue number10
DOIs
StatePublished - Oct 2008

Keywords

  • Body mass index
  • Carotenoids
  • Low-density lipoproteins
  • Obesity
  • Oxidative stress

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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