Circulating monocytes are not a major reservoir of HIV-1 in elite suppressors

Adam M. Spivak, Maria Salgado, S. Alireza Rabi, Karen A. O'Connell, Joel N. Blankson

Research output: Contribution to journalComment/debate

Abstract

Circulating HIV-1-infected monocytes have been identified in patients on highly active antiretroviral therapy and may represent an important barrier to viral eradication. The nature of these cells in HIV-1-infected patients who maintain undetectable viral loads and preserved CD4 + T cell counts without antiretroviral therapy (known as elite controllers or elite suppressors [ES]) is unknown. We describe here infrequent recovery of proviral HIV-1 DNA from circulating monocytes relative to CD4 + T cells in ES, despite permissiveness of these cells to HIV-1 viral entry ex vivo. Thus, monocytes do not appear to be a major reservoir of HIV-1 in ES.

Original languageEnglish (US)
Pages (from-to)10399-10403
Number of pages5
JournalJournal of virology
Volume85
Issue number19
DOIs
StatePublished - Oct 1 2011

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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