Abstract
Circulating HIV-1-infected monocytes have been identified in patients on highly active antiretroviral therapy and may represent an important barrier to viral eradication. The nature of these cells in HIV-1-infected patients who maintain undetectable viral loads and preserved CD4 + T cell counts without antiretroviral therapy (known as elite controllers or elite suppressors [ES]) is unknown. We describe here infrequent recovery of proviral HIV-1 DNA from circulating monocytes relative to CD4 + T cells in ES, despite permissiveness of these cells to HIV-1 viral entry ex vivo. Thus, monocytes do not appear to be a major reservoir of HIV-1 in ES.
Original language | English (US) |
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Pages (from-to) | 10399-10403 |
Number of pages | 5 |
Journal | Journal of virology |
Volume | 85 |
Issue number | 19 |
DOIs |
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State | Published - Oct 2011 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology