Circulating levels of cytokines during pregnancy: thrombopoietin is elevated in miscarriage

Brian W. Whitcomb, Enrique F. Schisterman, Mark A. Klebanoff, Mona Baumgarten, Xiaoping Luo, Nasser Chegini

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Objective: To evaluate the hypothesis that cytokine levels are associated with miscarriage risk using serum samples collected before report of miscarriage. Design: A nested case-control study. Setting: Biospecimens from the multisite Collaborative Perinatal Project, University of Florida, laboratory assessment of interleukin (IL)-1 receptor antagonist, IL-1β, IL-4, IL-6, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, thrombopoietin (TPO), and granulocyte colony-stimulating factor (G-CSF). Patient(s): Cases of miscarriage (n = 439) were matched to controls (n = 373) by gestational age at sample collection. Intervention(s): None. Main Outcome Measure(s): Miscarriage. Result(s): Increased risk of miscarriage was associated with elevated TPO (adjusted odds ratio [OR] 1.16, 95% confidence interval [CI] 1.00-1.36) and decreased G-CSF (adjusted OR 0.78, 95% CI 0.64-0.95). When analysis was restricted to samples collected more than 35 days before miscarriage, the effect of G-CSF was not observed (adjusted OR 0.96, 95% CI 0.72-1.28), whereas increased risk related to higher TPO remained. Conclusion(s): Circulating levels of TPO may be associated with increased risk of miscarriage.

Original languageEnglish (US)
Pages (from-to)1795-1802
Number of pages8
JournalFertility and Sterility
Issue number6
StatePublished - Jun 2008
Externally publishedYes


  • Cytokines
  • epidemiology
  • hematopoiesis
  • miscarriage
  • placentation

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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