TY - JOUR
T1 - Circulating levels of cytokines during pregnancy
T2 - thrombopoietin is elevated in miscarriage
AU - Whitcomb, Brian W.
AU - Schisterman, Enrique F.
AU - Klebanoff, Mark A.
AU - Baumgarten, Mona
AU - Luo, Xiaoping
AU - Chegini, Nasser
N1 - Funding Information:
Funded by an intramural grant from the Epidemiology Branch of the Division of Epidemiology, Statistics and Prevention Research at the National Institute of Child Health and Human Development.
PY - 2008/6
Y1 - 2008/6
N2 - Objective: To evaluate the hypothesis that cytokine levels are associated with miscarriage risk using serum samples collected before report of miscarriage. Design: A nested case-control study. Setting: Biospecimens from the multisite Collaborative Perinatal Project, University of Florida, laboratory assessment of interleukin (IL)-1 receptor antagonist, IL-1β, IL-4, IL-6, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, thrombopoietin (TPO), and granulocyte colony-stimulating factor (G-CSF). Patient(s): Cases of miscarriage (n = 439) were matched to controls (n = 373) by gestational age at sample collection. Intervention(s): None. Main Outcome Measure(s): Miscarriage. Result(s): Increased risk of miscarriage was associated with elevated TPO (adjusted odds ratio [OR] 1.16, 95% confidence interval [CI] 1.00-1.36) and decreased G-CSF (adjusted OR 0.78, 95% CI 0.64-0.95). When analysis was restricted to samples collected more than 35 days before miscarriage, the effect of G-CSF was not observed (adjusted OR 0.96, 95% CI 0.72-1.28), whereas increased risk related to higher TPO remained. Conclusion(s): Circulating levels of TPO may be associated with increased risk of miscarriage.
AB - Objective: To evaluate the hypothesis that cytokine levels are associated with miscarriage risk using serum samples collected before report of miscarriage. Design: A nested case-control study. Setting: Biospecimens from the multisite Collaborative Perinatal Project, University of Florida, laboratory assessment of interleukin (IL)-1 receptor antagonist, IL-1β, IL-4, IL-6, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, thrombopoietin (TPO), and granulocyte colony-stimulating factor (G-CSF). Patient(s): Cases of miscarriage (n = 439) were matched to controls (n = 373) by gestational age at sample collection. Intervention(s): None. Main Outcome Measure(s): Miscarriage. Result(s): Increased risk of miscarriage was associated with elevated TPO (adjusted odds ratio [OR] 1.16, 95% confidence interval [CI] 1.00-1.36) and decreased G-CSF (adjusted OR 0.78, 95% CI 0.64-0.95). When analysis was restricted to samples collected more than 35 days before miscarriage, the effect of G-CSF was not observed (adjusted OR 0.96, 95% CI 0.72-1.28), whereas increased risk related to higher TPO remained. Conclusion(s): Circulating levels of TPO may be associated with increased risk of miscarriage.
KW - Cytokines
KW - epidemiology
KW - hematopoiesis
KW - miscarriage
KW - placentation
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U2 - 10.1016/j.fertnstert.2007.05.046
DO - 10.1016/j.fertnstert.2007.05.046
M3 - Article
C2 - 17706203
AN - SCOPUS:44349145931
SN - 0015-0282
VL - 89
SP - 1795
EP - 1802
JO - Fertility and sterility
JF - Fertility and sterility
IS - 6
ER -