Circulating levels of carboxy-methyl-lysine (CML) are associated with hip fracture risk: The cardiovascular health study

Joshua I. Barzilay, Petra Bůžková, Susan J. Zieman, Jorge R. Kizer, Luc Djoussé, Joachim H. Ix, Russell P. Tracy, David S. Siscovick, Jane A. Cauley, Kenneth J. Mukamal

Research output: Contribution to journalArticle

Abstract

Advanced glycation end products (AGE) in bone tissue are associated with impaired biomechanical properties and increased fracture risk. Here we examine whether serum levels of the AGE carboxy-methyl-lysine (CML) are associated with risk of hip fracture. We followed 3373 participants from the Cardiovascular Health Study (age 78 years; range, 68-102 years; 39.8% male) for a median of 9.22 years (range, 0.01-12.07 years). Rates of incident hip fracture were calculated by quartiles of baseline CML levels, and hazard ratios were adjusted for covariates associated with hip fracture risk. A subcohort of 1315 participants had bone mineral density (BMD) measurement. There were 348 hip fractures during follow-up, with incidence rates of hip fracture by CML quartiles of 0.94, 1.34, 1.18, and 1.69 per 100 participant-years. The unadjusted hazard ratio of hip fracture increased with each 1 SD increase (189ng/mL) of CML level (hazard ratio, 1.27; 95% confidence interval [CI], 1.16-1.40]; p

Original languageEnglish (US)
Pages (from-to)1061-1066
Number of pages6
JournalJournal of Bone and Mineral Research
Volume29
Issue number5
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • bone mineral density
  • bone quality
  • carboxy-methyl-lysine
  • cardiovascular health study
  • hip fracture risk

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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    Barzilay, J. I., Bůžková, P., Zieman, S. J., Kizer, J. R., Djoussé, L., Ix, J. H., Tracy, R. P., Siscovick, D. S., Cauley, J. A., & Mukamal, K. J. (2014). Circulating levels of carboxy-methyl-lysine (CML) are associated with hip fracture risk: The cardiovascular health study. Journal of Bone and Mineral Research, 29(5), 1061-1066. https://doi.org/10.1002/jbmr.2123