We evaluated interleukin (IL)-6 and IL-8 as early markers of serious infection in febrile neutropenic children and found that both molecules had limited diagnostic value. Although the promoter polymorphisms IL-6 G-174C and IL-8 A-251T influence serum concentrations of the respective cytokines, genotyping for these polymorphisms does not improve the diagnostic value of IL-6 and IL-8 measurements.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Feb 2004|
- Febrile neutropenia
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