Circulating levels and promoter polymorphisms of interleukins-6 and 8 in pediatric cancer patients with fever and neutropenia

Thomas Lehrnbecher; Gudrun Fleischhack; Mitra Hanisch; Frank Deinlein; Arne Simon; Toralf Bernig; Stephen J. Chanock; Thomas Klingebiel

Circulating levels and promoter polymorphisms of interleukins-6 and 8 in pediatric cancer patients with fever and neutropenia

Thomas Lehrnbecher, Gudrun Fleischhack, Mitra Hanisch, Frank Deinlein, Arne Simon, Toralf Bernig, Stephen J. Chanock, Thomas Klingebiel

School of Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We evaluated interleukin (IL)-6 and IL-8 as early markers of serious infection in febrile neutropenic children and found that both molecules had limited diagnostic value. Although the promoter polymorphisms IL-6 G-174C and IL-8 A-251T influence serum concentrations of the respective cytokines, genotyping for these polymorphisms does not improve the diagnostic value of IL-6 and IL-8 measurements.

Original language	English (US)
Pages (from-to)	234-236
Number of pages	3
Journal	Haematologica
Volume	89
Issue number	2
State	Published - Feb 2004

Keywords

Chemotherapy
Children
Febrile neutropenia
Interleukin
Polymorphisms

ASJC Scopus subject areas

Hematology

Cite this

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title = "Circulating levels and promoter polymorphisms of interleukins-6 and 8 in pediatric cancer patients with fever and neutropenia",

abstract = "We evaluated interleukin (IL)-6 and IL-8 as early markers of serious infection in febrile neutropenic children and found that both molecules had limited diagnostic value. Although the promoter polymorphisms IL-6 G-174C and IL-8 A-251T influence serum concentrations of the respective cytokines, genotyping for these polymorphisms does not improve the diagnostic value of IL-6 and IL-8 measurements.",

keywords = "Chemotherapy, Children, Febrile neutropenia, Interleukin, Polymorphisms",

author = "Thomas Lehrnbecher and Gudrun Fleischhack and Mitra Hanisch and Frank Deinlein and Arne Simon and Toralf Bernig and Chanock, {Stephen J.} and Thomas Klingebiel",

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AU - Lehrnbecher, Thomas

AU - Fleischhack, Gudrun

AU - Hanisch, Mitra

AU - Deinlein, Frank

AU - Simon, Arne

AU - Bernig, Toralf

AU - Chanock, Stephen J.

AU - Klingebiel, Thomas

PY - 2004/2

Y1 - 2004/2

N2 - We evaluated interleukin (IL)-6 and IL-8 as early markers of serious infection in febrile neutropenic children and found that both molecules had limited diagnostic value. Although the promoter polymorphisms IL-6 G-174C and IL-8 A-251T influence serum concentrations of the respective cytokines, genotyping for these polymorphisms does not improve the diagnostic value of IL-6 and IL-8 measurements.

AB - We evaluated interleukin (IL)-6 and IL-8 as early markers of serious infection in febrile neutropenic children and found that both molecules had limited diagnostic value. Although the promoter polymorphisms IL-6 G-174C and IL-8 A-251T influence serum concentrations of the respective cytokines, genotyping for these polymorphisms does not improve the diagnostic value of IL-6 and IL-8 measurements.

KW - Chemotherapy

KW - Children

KW - Febrile neutropenia

KW - Interleukin

KW - Polymorphisms

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SN - 0390-6078

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JO - Haematologica

JF - Haematologica

IS - 2

ER -

Circulating levels and promoter polymorphisms of interleukins-6 and 8 in pediatric cancer patients with fever and neutropenia

Abstract

Keywords

ASJC Scopus subject areas

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