Circulating levels and promoter polymorphisms of interleukins-6 and 8 in pediatric cancer patients with fever and neutropenia

Thomas Lehrnbecher, Gudrun Fleischhack, Mitra Hanisch, Frank Deinlein, Arne Simon, Toralf Bernig, Stephen J. Chanock, Thomas Klingebiel

Research output: Contribution to journalArticle

Abstract

We evaluated interleukin (IL)-6 and IL-8 as early markers of serious infection in febrile neutropenic children and found that both molecules had limited diagnostic value. Although the promoter polymorphisms IL-6 G-174C and IL-8 A-251T influence serum concentrations of the respective cytokines, genotyping for these polymorphisms does not improve the diagnostic value of IL-6 and IL-8 measurements.

Original languageEnglish (US)
Pages (from-to)234-236
Number of pages3
JournalHaematologica
Volume89
Issue number2
StatePublished - Feb 1 2004

Keywords

  • Chemotherapy
  • Children
  • Febrile neutropenia
  • Interleukin
  • Polymorphisms

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Circulating levels and promoter polymorphisms of interleukins-6 and 8 in pediatric cancer patients with fever and neutropenia'. Together they form a unique fingerprint.

  • Cite this

    Lehrnbecher, T., Fleischhack, G., Hanisch, M., Deinlein, F., Simon, A., Bernig, T., Chanock, S. J., & Klingebiel, T. (2004). Circulating levels and promoter polymorphisms of interleukins-6 and 8 in pediatric cancer patients with fever and neutropenia. Haematologica, 89(2), 234-236.