Circulating immune complexes in bacillary and amebic dysentery

F. T. Koster, K. S K Tung, Robert H Gilman, A. Ahmed, M. M. Rahaman, R. C. Williams

Research output: Contribution to journalArticle

Abstract

In order to study the relationship between the presence of circulating immune complexes (CIC) and the severity and duration of acute dysentery, we studied 11 adults and 45 children in Bangladesh with bacillary and amebic dysentery, using the Raji cell and solid-phase C1q (C1q-SPA) assays. CIC were found in 70% of patients with shigellosis and in all eight cases of amebic dysentery. Mild shigellosis was associated with positive samples in the first week of clinical illness, whereas severe cases, including those with the hemolytic-uremic syndrome, had negative admission assays but positive convalescent assays. Samples positive in the first two weeks of illness were more likely positive by the Raji cell assay alone whereas samples in the third and fourth weeks of illness were positive more often by the C1q-SPA assay. Only one shigellosis sample was positive by both assays. In amebiasis 11 of 13 samples were positive by the Raji assay alone. In dysenteric disease circulating immune complexes probably represent the failure of the inflamed mucosa to exclude microbial and dietary antigens, and suggest that the presence of CIC in any intestinal disease must be interpreted with caution.

Original languageEnglish (US)
Pages (from-to)153-157
Number of pages5
JournalJournal of Clinical and Laboratory Immunology
Volume5
Issue number3
StatePublished - 1981

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Amoebic Dysentery
Bacillary Dysentery
Antigen-Antibody Complex
Immune Complex Diseases
Amebiasis
Intestinal Diseases
Dysentery
Hemolytic-Uremic Syndrome
Bangladesh
Mucous Membrane
Antigens

ASJC Scopus subject areas

  • Immunology

Cite this

Koster, F. T., Tung, K. S. K., Gilman, R. H., Ahmed, A., Rahaman, M. M., & Williams, R. C. (1981). Circulating immune complexes in bacillary and amebic dysentery. Journal of Clinical and Laboratory Immunology, 5(3), 153-157.

Circulating immune complexes in bacillary and amebic dysentery. / Koster, F. T.; Tung, K. S K; Gilman, Robert H; Ahmed, A.; Rahaman, M. M.; Williams, R. C.

In: Journal of Clinical and Laboratory Immunology, Vol. 5, No. 3, 1981, p. 153-157.

Research output: Contribution to journalArticle

Koster, FT, Tung, KSK, Gilman, RH, Ahmed, A, Rahaman, MM & Williams, RC 1981, 'Circulating immune complexes in bacillary and amebic dysentery', Journal of Clinical and Laboratory Immunology, vol. 5, no. 3, pp. 153-157.
Koster, F. T. ; Tung, K. S K ; Gilman, Robert H ; Ahmed, A. ; Rahaman, M. M. ; Williams, R. C. / Circulating immune complexes in bacillary and amebic dysentery. In: Journal of Clinical and Laboratory Immunology. 1981 ; Vol. 5, No. 3. pp. 153-157.
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