Circulating HFMD-associated coxsackievirus A16 is genetically and phenotypically distinct from the prototype CV-A16

Wei Wei, Haoran Guo, Jingliang Li, Sangsang Ren, Zhenhong Wei, Wanguo Bao, Xiaoming Hu, Ke Zhao, Wenyan Zhang, Yulai Zhou, Fei Sun, Richard Markham, Xiao Fang Yu

Research output: Contribution to journalArticlepeer-review

Abstract

Human enteroviruses (HEV) have been linked to hand, foot, and mouth disease (HFMD) in the Pacific and Southeast Asia for decades. Many cases of HFMD have been attributed to coxsackievirus A16 (CV-A16, CA16), based on only partial viral genome determination. Viral phenotypes are also poorly defined. Herein, we have genetically and phenotypically characterized multiple circulating CV-A16 viruses from HFMD patients and determined multiple full-length sequences of these circulating viruses. We discovered that the circulating CV-A16 viruses from HFMD patients are genetically distinct from the proto-type CV-A16 G10. We have also isolated circulating CV-A16 viruses from hospitalized HFMD patients and compared their virological differences. Interestingly, circulating CV-A16 viruses are more pathogenic in a neonatal mouse model than is CV-A16 G10. Thus, we have found circulating recombinant forms of CV-A16 (CRF CV-A16) that are related to, but different from, the prototype CV-A16 G10 that have distinct biological phenotypes.

Original languageEnglish (US)
Article numbere94746
JournalPloS one
Volume9
Issue number4
DOIs
StatePublished - Apr 15 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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