Circulating glycotoxins and dietary advanced glycation endproducts: Two links to inflammatory response, oxidative stress, and aging

Jaime Uribarri, Weijing Cai, Melpomeni Peppa, Susan Goodman, Luigi Ferrucci, Gary Striker, Helen Vlassara

Research output: Contribution to journalArticle

Abstract

Background. Oxidative stress (OS) and inflammatory mediators increase with aging. The levels of advanced glycation endproducts (AGEs), prooxidant factors linked to chronic diseases such as diabetes, cardiovascular disease, and renal disease, also increase with aging. AGEs are readily derived from heat-treated foods. We propose that the excess consumption of certain AGEs via the diet enhances OS and inflammatory responses in healthy adults, especially in elderly persons. Methods. We examined 172 young (60 years old) healthy individuals to determine whether the concentration of specific serum AGEs (Nε-carboxymethyl-lysine [CML] or methylglyoxal [MG] derivatives) were higher in older compared to younger persons and whether, independent of age, they correlated with the intake of dietary AGEs, as well as with circulating markers of OS and inflammation. Results. Body weight, body mass index (BMI), and serum AGE, CML, and MG derivatives were higher in older participants, independent of gender. Serum CML correlated with levels of 8-isoprostanes (r = 0.448, p = .0001) as well as with Homeostasis Model Assessment index (HOMA), an index of insulin resistance (r = 0.247, p = .044). The consumption of dietary AGEs, but not of calories, correlated independently with circulating AGEs (CML: r = 0.415, p = .0001 and MG: r = 0.282, p = .002) as well as with high sensitivity C-reactive protein (hsCRP) (r = 0.200, p = .042). Conclusions. Circulating indicators of AGEs (CML and MG derivatives), although elevated in older participants, correlate with indicators of inflammation and OS across all ages. Indicators of both AGEs and OS are directly influenced by the intake of dietary AGEs, independent of age or energy intake. Thus, reduced consumption of these oxidants may prove a safe economic policy to prevent age-related diseases, especially in an aging population.

Original languageEnglish (US)
Pages (from-to)427-433
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume62
Issue number4
StatePublished - Apr 2007
Externally publishedYes

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Pyruvaldehyde
Oxidative Stress
8-epi-prostaglandin F2alpha
Serum
Inflammation
Energy Intake
Oxidants
C-Reactive Protein
Insulin Resistance
Body Mass Index
Homeostasis
Chronic Disease
Cardiovascular Diseases
Hot Temperature
Body Weight
Economics
N(6)-carboxymethyllysine
Diet
Kidney
Food

ASJC Scopus subject areas

  • Aging

Cite this

Circulating glycotoxins and dietary advanced glycation endproducts : Two links to inflammatory response, oxidative stress, and aging. / Uribarri, Jaime; Cai, Weijing; Peppa, Melpomeni; Goodman, Susan; Ferrucci, Luigi; Striker, Gary; Vlassara, Helen.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 62, No. 4, 04.2007, p. 427-433.

Research output: Contribution to journalArticle

Uribarri, Jaime ; Cai, Weijing ; Peppa, Melpomeni ; Goodman, Susan ; Ferrucci, Luigi ; Striker, Gary ; Vlassara, Helen. / Circulating glycotoxins and dietary advanced glycation endproducts : Two links to inflammatory response, oxidative stress, and aging. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2007 ; Vol. 62, No. 4. pp. 427-433.
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T1 - Circulating glycotoxins and dietary advanced glycation endproducts

T2 - Two links to inflammatory response, oxidative stress, and aging

AU - Uribarri, Jaime

AU - Cai, Weijing

AU - Peppa, Melpomeni

AU - Goodman, Susan

AU - Ferrucci, Luigi

AU - Striker, Gary

AU - Vlassara, Helen

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N2 - Background. Oxidative stress (OS) and inflammatory mediators increase with aging. The levels of advanced glycation endproducts (AGEs), prooxidant factors linked to chronic diseases such as diabetes, cardiovascular disease, and renal disease, also increase with aging. AGEs are readily derived from heat-treated foods. We propose that the excess consumption of certain AGEs via the diet enhances OS and inflammatory responses in healthy adults, especially in elderly persons. Methods. We examined 172 young (60 years old) healthy individuals to determine whether the concentration of specific serum AGEs (Nε-carboxymethyl-lysine [CML] or methylglyoxal [MG] derivatives) were higher in older compared to younger persons and whether, independent of age, they correlated with the intake of dietary AGEs, as well as with circulating markers of OS and inflammation. Results. Body weight, body mass index (BMI), and serum AGE, CML, and MG derivatives were higher in older participants, independent of gender. Serum CML correlated with levels of 8-isoprostanes (r = 0.448, p = .0001) as well as with Homeostasis Model Assessment index (HOMA), an index of insulin resistance (r = 0.247, p = .044). The consumption of dietary AGEs, but not of calories, correlated independently with circulating AGEs (CML: r = 0.415, p = .0001 and MG: r = 0.282, p = .002) as well as with high sensitivity C-reactive protein (hsCRP) (r = 0.200, p = .042). Conclusions. Circulating indicators of AGEs (CML and MG derivatives), although elevated in older participants, correlate with indicators of inflammation and OS across all ages. Indicators of both AGEs and OS are directly influenced by the intake of dietary AGEs, independent of age or energy intake. Thus, reduced consumption of these oxidants may prove a safe economic policy to prevent age-related diseases, especially in an aging population.

AB - Background. Oxidative stress (OS) and inflammatory mediators increase with aging. The levels of advanced glycation endproducts (AGEs), prooxidant factors linked to chronic diseases such as diabetes, cardiovascular disease, and renal disease, also increase with aging. AGEs are readily derived from heat-treated foods. We propose that the excess consumption of certain AGEs via the diet enhances OS and inflammatory responses in healthy adults, especially in elderly persons. Methods. We examined 172 young (60 years old) healthy individuals to determine whether the concentration of specific serum AGEs (Nε-carboxymethyl-lysine [CML] or methylglyoxal [MG] derivatives) were higher in older compared to younger persons and whether, independent of age, they correlated with the intake of dietary AGEs, as well as with circulating markers of OS and inflammation. Results. Body weight, body mass index (BMI), and serum AGE, CML, and MG derivatives were higher in older participants, independent of gender. Serum CML correlated with levels of 8-isoprostanes (r = 0.448, p = .0001) as well as with Homeostasis Model Assessment index (HOMA), an index of insulin resistance (r = 0.247, p = .044). The consumption of dietary AGEs, but not of calories, correlated independently with circulating AGEs (CML: r = 0.415, p = .0001 and MG: r = 0.282, p = .002) as well as with high sensitivity C-reactive protein (hsCRP) (r = 0.200, p = .042). Conclusions. Circulating indicators of AGEs (CML and MG derivatives), although elevated in older participants, correlate with indicators of inflammation and OS across all ages. Indicators of both AGEs and OS are directly influenced by the intake of dietary AGEs, independent of age or energy intake. Thus, reduced consumption of these oxidants may prove a safe economic policy to prevent age-related diseases, especially in an aging population.

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