Circulating cytokine levels predict the severity of renal failure in classic hemolytic uremic syndrome (HUS)

Catherine Litalien, François Proulx, Michelle M. Mariscalco, Pierre Robitaille, Jean P. Turgeon, Elaine Orrbine, Peter Rowe, Peter N. McLaine, Ernest Seidman

Research output: Contribution to journalArticle

Abstract

Introduction: Verotoxin-producing Escherichia coli (VTEC) cause hemorrhagic colitis (HC) Which may lead to HUS in 10% of cases. Experimental data suggests that the inflammatory response of the host is involved in the pathophysiology of VTEC infections. Methods: We measured the circulating levels of pro- [interleukin (IL)-6, IL-8] and anti-inflammatory [IL-10 and IL-1 receptor antagonist (Ra)] mediators in serum samples obtained on admission, among 38 children with HUS due to Escherichia coli O157:H7 and among 12 normal controls. We compared the cytokine levels according to the severity of renal dysfunction. The latter was evaluated by the occurrence of oligoanuria, the requirement of dialysis, and a glomerular filtration rate (GFR) ≤80 mL/min/1.73 m 2 measured 1 year after enrolment. Results: Increased levels of IL-6, IL-10 and IL-1Ra were found in patients with HUS compared to controls (p

Original languageEnglish (US)
JournalCritical Care Medicine
Volume27
Issue number1 SUPPL.
StatePublished - 1999
Externally publishedYes

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Hemolytic-Uremic Syndrome
Renal Insufficiency
Shiga-Toxigenic Escherichia coli
Cytokines
Interleukin-10
Interleukin-6
Escherichia coli Infections
Escherichia coli O157
Interleukin-1 Receptors
Interleukins
Colitis
Glomerular Filtration Rate
Interleukin-8
Dialysis
Anti-Inflammatory Agents
Kidney
Serum

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Litalien, C., Proulx, F., Mariscalco, M. M., Robitaille, P., Turgeon, J. P., Orrbine, E., ... Seidman, E. (1999). Circulating cytokine levels predict the severity of renal failure in classic hemolytic uremic syndrome (HUS). Critical Care Medicine, 27(1 SUPPL.).

Circulating cytokine levels predict the severity of renal failure in classic hemolytic uremic syndrome (HUS). / Litalien, Catherine; Proulx, François; Mariscalco, Michelle M.; Robitaille, Pierre; Turgeon, Jean P.; Orrbine, Elaine; Rowe, Peter; McLaine, Peter N.; Seidman, Ernest.

In: Critical Care Medicine, Vol. 27, No. 1 SUPPL., 1999.

Research output: Contribution to journalArticle

Litalien, C, Proulx, F, Mariscalco, MM, Robitaille, P, Turgeon, JP, Orrbine, E, Rowe, P, McLaine, PN & Seidman, E 1999, 'Circulating cytokine levels predict the severity of renal failure in classic hemolytic uremic syndrome (HUS)', Critical Care Medicine, vol. 27, no. 1 SUPPL..
Litalien C, Proulx F, Mariscalco MM, Robitaille P, Turgeon JP, Orrbine E et al. Circulating cytokine levels predict the severity of renal failure in classic hemolytic uremic syndrome (HUS). Critical Care Medicine. 1999;27(1 SUPPL.).
Litalien, Catherine ; Proulx, François ; Mariscalco, Michelle M. ; Robitaille, Pierre ; Turgeon, Jean P. ; Orrbine, Elaine ; Rowe, Peter ; McLaine, Peter N. ; Seidman, Ernest. / Circulating cytokine levels predict the severity of renal failure in classic hemolytic uremic syndrome (HUS). In: Critical Care Medicine. 1999 ; Vol. 27, No. 1 SUPPL.
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AU - Proulx, François

AU - Mariscalco, Michelle M.

AU - Robitaille, Pierre

AU - Turgeon, Jean P.

AU - Orrbine, Elaine

AU - Rowe, Peter

AU - McLaine, Peter N.

AU - Seidman, Ernest

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