Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis.

Marcia C. de Oliveira Otto, Jason H Y Wu, Ana Baylin, Dhananjay Vaidya, Stephen S. Rich, Michael Y. Tsai, David R. Jacobs, Dariush Mozaffarian

Research output: Contribution to journalArticle

Abstract

Dietary guidelines support intake of polyunsaturated fatty acids (PUFAs) in fish and vegetable oils. However, some controversy remains about benefits of PUFAs, and most prior studies have relied on self-reported dietary assessment in relatively homogeneous populations. In a multiethnic cohort of 2837 US adults (whites, Hispanics, African Americans, Chinese Americans), plasma phospholipid PUFAs were measured at baseline (2000-2002) using gas chromatography and dietary PUFAs estimated using a food frequency questionnaire. Incident cardiovascular disease (CVD) events (including coronary heart disease and stroke; n=189) were prospectively identified through 2010 during 19 778 person-years of follow-up. In multivariable-adjusted Cox models, circulating n-3 eicosapentaenoic acid and docosahexaenoic acid were inversely associated with incident CVD, with extreme-quartile hazard ratios (95% CIs) of 0.49 for eicosapentaenoic acid (0.30 to 0.79; Ptrend=0.01) and 0.39 for docosahexaenoic acid (0.22 to 0.67; Ptrend

Original languageEnglish (US)
JournalJournal of the American Heart Association
Volume2
Issue number6
StatePublished - Dec 2013

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Omega-6 Fatty Acids
Unsaturated Fatty Acids
Atherosclerosis
Cardiovascular Diseases
Eicosapentaenoic Acid
Docosahexaenoic Acids
Incidence
Nutrition Policy
Plant Oils
Asian Americans
Fish Oils
Hispanic Americans
Proportional Hazards Models
African Americans
Gas Chromatography
Coronary Disease
Phospholipids
Stroke
Food
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. / de Oliveira Otto, Marcia C.; Wu, Jason H Y; Baylin, Ana; Vaidya, Dhananjay; Rich, Stephen S.; Tsai, Michael Y.; Jacobs, David R.; Mozaffarian, Dariush.

In: Journal of the American Heart Association, Vol. 2, No. 6, 12.2013.

Research output: Contribution to journalArticle

de Oliveira Otto, Marcia C. ; Wu, Jason H Y ; Baylin, Ana ; Vaidya, Dhananjay ; Rich, Stephen S. ; Tsai, Michael Y. ; Jacobs, David R. ; Mozaffarian, Dariush. / Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. In: Journal of the American Heart Association. 2013 ; Vol. 2, No. 6.
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