Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Wei Zheng, Kim N. Danforth, Shelley S. Tworoger, Marc T. Goodman, Alan A. Arslan, Alpa V. Patel, Marjorie L. McCullough, Stephanie J. Weinstein, Laurence N. Kolonel, Mark P. Purdue, Xiao Ou Shu, Kirk Snyder, Emily Steplowski, Kala Visvanathan, Kai Yu, Anne Zeleniuch-Jacquotte, Yu Tang Gao, Susan E. Hankinson, Chinonye Harvey, Richard B. HayesBrian E. Henderson, Ronald L. Horst, Kathy J. Helzlsouer

Research output: Contribution to journalArticle

Abstract

A role for vitamin D in ovarian cancer etiology is supported by ecologic studies of sunlight exposure, experimental mechanism studies, and some studies of dietary vitamin D intake and genetic polymorphisms in the vitamin D receptor. However, few studies have examined the association of circulating 25-hydroxyvitamin D (25(OH)D), an integrated measure of vitamin D status, with ovarian cancer risk. A nested case-control study was conducted among 7 prospective studies to evaluate the circulating 25(OH)D concentration in relation to epithelial ovarian cancer risk. Logistic regression models were used to estimate odds ratios and 95% confidence intervals among 516 cases and 770 matched controls. Compared with 25(OH)D concentrations of 50-2 (Pinteraction <0.01). In conclusion, this large pooled analysis did not support an overall association between circulating 25(OH)D and ovarian cancer risk, except possibly among overweight women.

Original languageEnglish (US)
Pages (from-to)70-80
Number of pages11
JournalAmerican Journal of Epidemiology
Volume172
Issue number1
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Vitamin D
Ovarian Neoplasms
Logistic Models
Neoplasms
Calcitriol Receptors
Sunlight
Genetic Polymorphisms
Case-Control Studies
Odds Ratio
Prospective Studies
Confidence Intervals
Ovarian epithelial cancer
25-hydroxyvitamin D

Keywords

  • Case-control studies
  • Cohort studies
  • Ovarian neoplasms
  • Prospective studies
  • Vitamin D

ASJC Scopus subject areas

  • Epidemiology

Cite this

Zheng, W., Danforth, K. N., Tworoger, S. S., Goodman, M. T., Arslan, A. A., Patel, A. V., ... Helzlsouer, K. J. (2010). Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. American Journal of Epidemiology, 172(1), 70-80. https://doi.org/10.1093/aje/kwq118

Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer : Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. / Zheng, Wei; Danforth, Kim N.; Tworoger, Shelley S.; Goodman, Marc T.; Arslan, Alan A.; Patel, Alpa V.; McCullough, Marjorie L.; Weinstein, Stephanie J.; Kolonel, Laurence N.; Purdue, Mark P.; Shu, Xiao Ou; Snyder, Kirk; Steplowski, Emily; Visvanathan, Kala; Yu, Kai; Zeleniuch-Jacquotte, Anne; Gao, Yu Tang; Hankinson, Susan E.; Harvey, Chinonye; Hayes, Richard B.; Henderson, Brian E.; Horst, Ronald L.; Helzlsouer, Kathy J.

In: American Journal of Epidemiology, Vol. 172, No. 1, 2010, p. 70-80.

Research output: Contribution to journalArticle

Zheng, W, Danforth, KN, Tworoger, SS, Goodman, MT, Arslan, AA, Patel, AV, McCullough, ML, Weinstein, SJ, Kolonel, LN, Purdue, MP, Shu, XO, Snyder, K, Steplowski, E, Visvanathan, K, Yu, K, Zeleniuch-Jacquotte, A, Gao, YT, Hankinson, SE, Harvey, C, Hayes, RB, Henderson, BE, Horst, RL & Helzlsouer, KJ 2010, 'Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers', American Journal of Epidemiology, vol. 172, no. 1, pp. 70-80. https://doi.org/10.1093/aje/kwq118
Zheng, Wei ; Danforth, Kim N. ; Tworoger, Shelley S. ; Goodman, Marc T. ; Arslan, Alan A. ; Patel, Alpa V. ; McCullough, Marjorie L. ; Weinstein, Stephanie J. ; Kolonel, Laurence N. ; Purdue, Mark P. ; Shu, Xiao Ou ; Snyder, Kirk ; Steplowski, Emily ; Visvanathan, Kala ; Yu, Kai ; Zeleniuch-Jacquotte, Anne ; Gao, Yu Tang ; Hankinson, Susan E. ; Harvey, Chinonye ; Hayes, Richard B. ; Henderson, Brian E. ; Horst, Ronald L. ; Helzlsouer, Kathy J. / Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer : Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. In: American Journal of Epidemiology. 2010 ; Vol. 172, No. 1. pp. 70-80.
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