Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Wei Zheng, Kim N. Danforth, Shelley S. Tworoger, Marc T. Goodman, Alan A. Arslan, Alpa V. Patel, Marjorie L. McCullough, Stephanie J. Weinstein, Laurence N. Kolonel, Mark P. Purdue, Xiao Ou Shu, Kirk Snyder, Emily Steplowski, Kala Visvanathan, Kai Yu, Anne Zeleniuch-Jacquotte, Yu Tang Gao, Susan E. Hankinson, Chinonye Harvey, Richard B. HayesBrian E. Henderson, Ronald L. Horst, Kathy J. Helzlsouer

Research output: Contribution to journalArticle

Abstract

A role for vitamin D in ovarian cancer etiology is supported by ecologic studies of sunlight exposure, experimental mechanism studies, and some studies of dietary vitamin D intake and genetic polymorphisms in the vitamin D receptor. However, few studies have examined the association of circulating 25-hydroxyvitamin D (25(OH)D), an integrated measure of vitamin D status, with ovarian cancer risk. A nested case-control study was conducted among 7 prospective studies to evaluate the circulating 25(OH)D concentration in relation to epithelial ovarian cancer risk. Logistic regression models were used to estimate odds ratios and 95% confidence intervals among 516 cases and 770 matched controls. Compared with 25(OH)D concentrations of 50-<75 nmol/L, no statistically significant associations were observed for <37.5 (odds ratio (OR) = 1.21, 95% confidence interval (CI): 0.87,1.70), 37.5-<50 (OR= 1.03, 95% CI: 0.75,1.41), or ≥75 (OR = 1.11, 95% CI: 0.79, 1.55) nmol/L. Analyses stratified by tumor subtype, age, body mass index, and other variables were generally null but suggested an inverse association between 25(OH)D and ovarian cancer risk among women with a body mass index of ≥25 kg/m 2 (Pinteraction < 0.01). In conclusion, this large pooled analysis did not support an overall association between circulating 25(OH)D and ovarian cancer risk, except possibly among overweight women.

Original languageEnglish (US)
Pages (from-to)70-80
Number of pages11
JournalAmerican journal of epidemiology
Volume172
Issue number1
DOIs
StatePublished - 2010

Keywords

  • Case-control studies
  • Cohort studies
  • Ovarian neoplasms
  • Prospective studies
  • Vitamin D

ASJC Scopus subject areas

  • Epidemiology

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    Zheng, W., Danforth, K. N., Tworoger, S. S., Goodman, M. T., Arslan, A. A., Patel, A. V., McCullough, M. L., Weinstein, S. J., Kolonel, L. N., Purdue, M. P., Shu, X. O., Snyder, K., Steplowski, E., Visvanathan, K., Yu, K., Zeleniuch-Jacquotte, A., Gao, Y. T., Hankinson, S. E., Harvey, C., ... Helzlsouer, K. J. (2010). Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. American journal of epidemiology, 172(1), 70-80. https://doi.org/10.1093/aje/kwq118