Circadian regulation of a transcription factor, ApC/EBP, in the eye of Aplysia californica

Samer Hattar, Lisa C. Lyons, Laurence Dryer, Arnold Eskin

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The transcription factor, ApC/EBP (Aplysia CCAAT enhancer-binding protein) is an immediate early gene that is rapidly induced by serotonin and the cAMP signaling pathway. ApC/EBP acts as an important link following the activation of protein kinase A (PKA) in the consolidation of long-term memory in Aplysia californica. In this study, we report that levels of ApC/EBP mRNA in the eye of Aplysia are modulated by serotonin or light. These responses of ApC/EBP to serotonin and light are mimicked by analogs of cAMP and cGMP. Expression of ApC/EBP in the eye is also under the control of the circadian oscillator with circadian rhythms of ApC/EBP mRNA present under constant dark conditions. Therefore, ApC/EBP is a candidate gene for a circadian transcription factor to mediate circadian responses activated by the cAMP and cGMP second messenger signaling pathways.

Original languageEnglish (US)
Pages (from-to)1401-1411
Number of pages11
JournalJournal of Neurochemistry
Issue number6
StatePublished - Dec 2002
Externally publishedYes


  • Aplysia californica
  • Biological clock
  • C/EBP
  • CAMP
  • Circadian rhythms
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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