Circadian regulation of a transcription factor, ApC/EBP, in the eye of Aplysia californica

Samer Hattar, Lisa C. Lyons, Laurence Dryer, Arnold Eskin

Research output: Contribution to journalArticle

Abstract

The transcription factor, ApC/EBP (Aplysia CCAAT enhancer-binding protein) is an immediate early gene that is rapidly induced by serotonin and the cAMP signaling pathway. ApC/EBP acts as an important link following the activation of protein kinase A (PKA) in the consolidation of long-term memory in Aplysia californica. In this study, we report that levels of ApC/EBP mRNA in the eye of Aplysia are modulated by serotonin or light. These responses of ApC/EBP to serotonin and light are mimicked by analogs of cAMP and cGMP. Expression of ApC/EBP in the eye is also under the control of the circadian oscillator with circadian rhythms of ApC/EBP mRNA present under constant dark conditions. Therefore, ApC/EBP is a candidate gene for a circadian transcription factor to mediate circadian responses activated by the cAMP and cGMP second messenger signaling pathways.

Original languageEnglish (US)
Pages (from-to)1401-1411
Number of pages11
JournalJournal of Neurochemistry
Volume83
Issue number6
DOIs
StatePublished - Dec 2002

Fingerprint

CCAAT-Enhancer-Binding Proteins
Aplysia
Transcription Factors
Serotonin
Genes
Messenger RNA
Second Messenger Systems
Cyclic AMP-Dependent Protein Kinases
Light
Consolidation
Immediate-Early Genes
Long-Term Memory
Circadian Rhythm
Chemical activation
Data storage equipment

Keywords

  • Aplysia californica
  • Biological clock
  • C/EBP
  • CAMP
  • Circadian rhythms
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Circadian regulation of a transcription factor, ApC/EBP, in the eye of Aplysia californica. / Hattar, Samer; Lyons, Lisa C.; Dryer, Laurence; Eskin, Arnold.

In: Journal of Neurochemistry, Vol. 83, No. 6, 12.2002, p. 1401-1411.

Research output: Contribution to journalArticle

Hattar, Samer ; Lyons, Lisa C. ; Dryer, Laurence ; Eskin, Arnold. / Circadian regulation of a transcription factor, ApC/EBP, in the eye of Aplysia californica. In: Journal of Neurochemistry. 2002 ; Vol. 83, No. 6. pp. 1401-1411.
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