Circadian regulation of a transcription factor, ApC/EBP, in the eye of Aplysia californica

Samer Hattar; Lisa C. Lyons; Laurence Dryer; Arnold Eskin

doi:10.1046/j.1471-4159.2002.01249.x

Circadian regulation of a transcription factor, ApC/EBP, in the eye of Aplysia californica

Samer Hattar, Lisa C. Lyons, Laurence Dryer, Arnold Eskin

School of Arts and Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The transcription factor, ApC/EBP (Aplysia CCAAT enhancer-binding protein) is an immediate early gene that is rapidly induced by serotonin and the cAMP signaling pathway. ApC/EBP acts as an important link following the activation of protein kinase A (PKA) in the consolidation of long-term memory in Aplysia californica. In this study, we report that levels of ApC/EBP mRNA in the eye of Aplysia are modulated by serotonin or light. These responses of ApC/EBP to serotonin and light are mimicked by analogs of cAMP and cGMP. Expression of ApC/EBP in the eye is also under the control of the circadian oscillator with circadian rhythms of ApC/EBP mRNA present under constant dark conditions. Therefore, ApC/EBP is a candidate gene for a circadian transcription factor to mediate circadian responses activated by the cAMP and cGMP second messenger signaling pathways.

Original language	English (US)
Pages (from-to)	1401-1411
Number of pages	11
Journal	Journal of Neurochemistry
Volume	83
Issue number	6
DOIs	https://doi.org/10.1046/j.1471-4159.2002.01249.x
State	Published - Dec 2002

Keywords

Aplysia californica
Biological clock
C/EBP
CAMP
Circadian rhythms
Serotonin

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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10.1046/j.1471-4159.2002.01249.x

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title = "Circadian regulation of a transcription factor, ApC/EBP, in the eye of Aplysia californica",

abstract = "The transcription factor, ApC/EBP (Aplysia CCAAT enhancer-binding protein) is an immediate early gene that is rapidly induced by serotonin and the cAMP signaling pathway. ApC/EBP acts as an important link following the activation of protein kinase A (PKA) in the consolidation of long-term memory in Aplysia californica. In this study, we report that levels of ApC/EBP mRNA in the eye of Aplysia are modulated by serotonin or light. These responses of ApC/EBP to serotonin and light are mimicked by analogs of cAMP and cGMP. Expression of ApC/EBP in the eye is also under the control of the circadian oscillator with circadian rhythms of ApC/EBP mRNA present under constant dark conditions. Therefore, ApC/EBP is a candidate gene for a circadian transcription factor to mediate circadian responses activated by the cAMP and cGMP second messenger signaling pathways.",

keywords = "Aplysia californica, Biological clock, C/EBP, CAMP, Circadian rhythms, Serotonin",

author = "Samer Hattar and Lyons, {Lisa C.} and Laurence Dryer and Arnold Eskin",

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AU - Lyons, Lisa C.

AU - Dryer, Laurence

AU - Eskin, Arnold

PY - 2002/12

Y1 - 2002/12

N2 - The transcription factor, ApC/EBP (Aplysia CCAAT enhancer-binding protein) is an immediate early gene that is rapidly induced by serotonin and the cAMP signaling pathway. ApC/EBP acts as an important link following the activation of protein kinase A (PKA) in the consolidation of long-term memory in Aplysia californica. In this study, we report that levels of ApC/EBP mRNA in the eye of Aplysia are modulated by serotonin or light. These responses of ApC/EBP to serotonin and light are mimicked by analogs of cAMP and cGMP. Expression of ApC/EBP in the eye is also under the control of the circadian oscillator with circadian rhythms of ApC/EBP mRNA present under constant dark conditions. Therefore, ApC/EBP is a candidate gene for a circadian transcription factor to mediate circadian responses activated by the cAMP and cGMP second messenger signaling pathways.

AB - The transcription factor, ApC/EBP (Aplysia CCAAT enhancer-binding protein) is an immediate early gene that is rapidly induced by serotonin and the cAMP signaling pathway. ApC/EBP acts as an important link following the activation of protein kinase A (PKA) in the consolidation of long-term memory in Aplysia californica. In this study, we report that levels of ApC/EBP mRNA in the eye of Aplysia are modulated by serotonin or light. These responses of ApC/EBP to serotonin and light are mimicked by analogs of cAMP and cGMP. Expression of ApC/EBP in the eye is also under the control of the circadian oscillator with circadian rhythms of ApC/EBP mRNA present under constant dark conditions. Therefore, ApC/EBP is a candidate gene for a circadian transcription factor to mediate circadian responses activated by the cAMP and cGMP second messenger signaling pathways.

KW - Aplysia californica

KW - Biological clock

KW - C/EBP

KW - CAMP

KW - Circadian rhythms

KW - Serotonin

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Circadian regulation of a transcription factor, ApC/EBP, in the eye of Aplysia californica

Abstract

Keywords

ASJC Scopus subject areas

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