Abstract
The transcription factor, ApC/EBP (Aplysia CCAAT enhancer-binding protein) is an immediate early gene that is rapidly induced by serotonin and the cAMP signaling pathway. ApC/EBP acts as an important link following the activation of protein kinase A (PKA) in the consolidation of long-term memory in Aplysia californica. In this study, we report that levels of ApC/EBP mRNA in the eye of Aplysia are modulated by serotonin or light. These responses of ApC/EBP to serotonin and light are mimicked by analogs of cAMP and cGMP. Expression of ApC/EBP in the eye is also under the control of the circadian oscillator with circadian rhythms of ApC/EBP mRNA present under constant dark conditions. Therefore, ApC/EBP is a candidate gene for a circadian transcription factor to mediate circadian responses activated by the cAMP and cGMP second messenger signaling pathways.
Original language | English (US) |
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Pages (from-to) | 1401-1411 |
Number of pages | 11 |
Journal | Journal of Neurochemistry |
Volume | 83 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2002 |
Externally published | Yes |
Keywords
- Aplysia californica
- Biological clock
- C/EBP
- CAMP
- Circadian rhythms
- Serotonin
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience