Abstract
The transcription factor, ApC/EBP (Aplysia CCAAT enhancer-binding protein) is an immediate early gene that is rapidly induced by serotonin and the cAMP signaling pathway. ApC/EBP acts as an important link following the activation of protein kinase A (PKA) in the consolidation of long-term memory in Aplysia californica. In this study, we report that levels of ApC/EBP mRNA in the eye of Aplysia are modulated by serotonin or light. These responses of ApC/EBP to serotonin and light are mimicked by analogs of cAMP and cGMP. Expression of ApC/EBP in the eye is also under the control of the circadian oscillator with circadian rhythms of ApC/EBP mRNA present under constant dark conditions. Therefore, ApC/EBP is a candidate gene for a circadian transcription factor to mediate circadian responses activated by the cAMP and cGMP second messenger signaling pathways.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1401-1411 |
| Number of pages | 11 |
| Journal | Journal of Neurochemistry |
| Volume | 83 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2002 |
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Keywords
- Aplysia californica
- Biological clock
- C/EBP
- CAMP
- Circadian rhythms
- Serotonin
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience
Cite this
Circadian regulation of a transcription factor, ApC/EBP, in the eye of Aplysia californica. / Hattar, Samer; Lyons, Lisa C.; Dryer, Laurence; Eskin, Arnold.
In: Journal of Neurochemistry, Vol. 83, No. 6, 12.2002, p. 1401-1411.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Circadian regulation of a transcription factor, ApC/EBP, in the eye of Aplysia californica
AU - Hattar, Samer
AU - Lyons, Lisa C.
AU - Dryer, Laurence
AU - Eskin, Arnold
PY - 2002/12
Y1 - 2002/12
N2 - The transcription factor, ApC/EBP (Aplysia CCAAT enhancer-binding protein) is an immediate early gene that is rapidly induced by serotonin and the cAMP signaling pathway. ApC/EBP acts as an important link following the activation of protein kinase A (PKA) in the consolidation of long-term memory in Aplysia californica. In this study, we report that levels of ApC/EBP mRNA in the eye of Aplysia are modulated by serotonin or light. These responses of ApC/EBP to serotonin and light are mimicked by analogs of cAMP and cGMP. Expression of ApC/EBP in the eye is also under the control of the circadian oscillator with circadian rhythms of ApC/EBP mRNA present under constant dark conditions. Therefore, ApC/EBP is a candidate gene for a circadian transcription factor to mediate circadian responses activated by the cAMP and cGMP second messenger signaling pathways.
AB - The transcription factor, ApC/EBP (Aplysia CCAAT enhancer-binding protein) is an immediate early gene that is rapidly induced by serotonin and the cAMP signaling pathway. ApC/EBP acts as an important link following the activation of protein kinase A (PKA) in the consolidation of long-term memory in Aplysia californica. In this study, we report that levels of ApC/EBP mRNA in the eye of Aplysia are modulated by serotonin or light. These responses of ApC/EBP to serotonin and light are mimicked by analogs of cAMP and cGMP. Expression of ApC/EBP in the eye is also under the control of the circadian oscillator with circadian rhythms of ApC/EBP mRNA present under constant dark conditions. Therefore, ApC/EBP is a candidate gene for a circadian transcription factor to mediate circadian responses activated by the cAMP and cGMP second messenger signaling pathways.
KW - Aplysia californica
KW - Biological clock
KW - C/EBP
KW - CAMP
KW - Circadian rhythms
KW - Serotonin
UR - http://www.scopus.com/inward/record.url?scp=0036906213&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036906213&partnerID=8YFLogxK
U2 - 10.1046/j.1471-4159.2002.01249.x
DO - 10.1046/j.1471-4159.2002.01249.x
M3 - Article
C2 - 12472894
AN - SCOPUS:0036906213
VL - 83
SP - 1401
EP - 1411
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
SN - 0022-3042
IS - 6
ER -