Cinchona alkaloids: Quinine and quinidine

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

For 400 years, quinine has been the effective antimalarial. From a pulverized bark, which stopped cyclic fevers, to an easily isolated crystal alkaloid, which launched many pharmaceutical companies, tons of quinine are still purified for medicinal and beverage use. The quest for quinine synthesis pioneered early medicinal dyes, antibacterials, and other drugs. In a specialized Plasmodium lysosome for hemoglobin degradation, quinine binds heme, which inhibits heme crystallization to kill rapidly. Although quinine drug resistance was described 100 years ago, unlike chloroquinine or the antifolates that have been rendered ineffective by the spread of resistant mutants, quinine has only a few persistent, resistant parasites worldwide. The artemisinin drugs, superior to quinine for severe malaria, have greatly reduced the use of quinine as an antimalarial. Evidence for prolonged artemisinin parasite clearance times both renews the quest for rapidly parasiticidal drugs for severe malaria and possibly holds a place for quinine.

Original languageEnglish (US)
Title of host publicationTreatment and Prevention of Malaria
Subtitle of host publicationAntimalarial Drug Chemistry, Action and Use
PublisherHumana Press Inc.
Pages45-68
Number of pages24
ISBN (Electronic)9783034604802
ISBN (Print)9783034604796
DOIs
StatePublished - Jan 1 2012

Fingerprint

Cinchona Alkaloids
Quinidine
Quinine
Antimalarials
Heme
Pharmaceutical Preparations
Malaria
Parasites
Folic Acid Antagonists
Plasmodium
Beverages
Crystallization
Lysosomes
Alkaloids
Drug Resistance
Hemoglobins
Fever
Coloring Agents

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Sullivan, D. J. (2012). Cinchona alkaloids: Quinine and quinidine. In Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use (pp. 45-68). Humana Press Inc.. https://doi.org/10.1007/978-3-0346-0480-2_3

Cinchona alkaloids : Quinine and quinidine. / Sullivan, David J.

Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use. Humana Press Inc., 2012. p. 45-68.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sullivan, DJ 2012, Cinchona alkaloids: Quinine and quinidine. in Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use. Humana Press Inc., pp. 45-68. https://doi.org/10.1007/978-3-0346-0480-2_3
Sullivan DJ. Cinchona alkaloids: Quinine and quinidine. In Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use. Humana Press Inc. 2012. p. 45-68 https://doi.org/10.1007/978-3-0346-0480-2_3
Sullivan, David J. / Cinchona alkaloids : Quinine and quinidine. Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use. Humana Press Inc., 2012. pp. 45-68
@inbook{d0439fdc0fd549ce98a6cec254d0d6cb,
title = "Cinchona alkaloids: Quinine and quinidine",
abstract = "For 400 years, quinine has been the effective antimalarial. From a pulverized bark, which stopped cyclic fevers, to an easily isolated crystal alkaloid, which launched many pharmaceutical companies, tons of quinine are still purified for medicinal and beverage use. The quest for quinine synthesis pioneered early medicinal dyes, antibacterials, and other drugs. In a specialized Plasmodium lysosome for hemoglobin degradation, quinine binds heme, which inhibits heme crystallization to kill rapidly. Although quinine drug resistance was described 100 years ago, unlike chloroquinine or the antifolates that have been rendered ineffective by the spread of resistant mutants, quinine has only a few persistent, resistant parasites worldwide. The artemisinin drugs, superior to quinine for severe malaria, have greatly reduced the use of quinine as an antimalarial. Evidence for prolonged artemisinin parasite clearance times both renews the quest for rapidly parasiticidal drugs for severe malaria and possibly holds a place for quinine.",
author = "Sullivan, {David J}",
year = "2012",
month = "1",
day = "1",
doi = "10.1007/978-3-0346-0480-2_3",
language = "English (US)",
isbn = "9783034604796",
pages = "45--68",
booktitle = "Treatment and Prevention of Malaria",
publisher = "Humana Press Inc.",

}

TY - CHAP

T1 - Cinchona alkaloids

T2 - Quinine and quinidine

AU - Sullivan, David J

PY - 2012/1/1

Y1 - 2012/1/1

N2 - For 400 years, quinine has been the effective antimalarial. From a pulverized bark, which stopped cyclic fevers, to an easily isolated crystal alkaloid, which launched many pharmaceutical companies, tons of quinine are still purified for medicinal and beverage use. The quest for quinine synthesis pioneered early medicinal dyes, antibacterials, and other drugs. In a specialized Plasmodium lysosome for hemoglobin degradation, quinine binds heme, which inhibits heme crystallization to kill rapidly. Although quinine drug resistance was described 100 years ago, unlike chloroquinine or the antifolates that have been rendered ineffective by the spread of resistant mutants, quinine has only a few persistent, resistant parasites worldwide. The artemisinin drugs, superior to quinine for severe malaria, have greatly reduced the use of quinine as an antimalarial. Evidence for prolonged artemisinin parasite clearance times both renews the quest for rapidly parasiticidal drugs for severe malaria and possibly holds a place for quinine.

AB - For 400 years, quinine has been the effective antimalarial. From a pulverized bark, which stopped cyclic fevers, to an easily isolated crystal alkaloid, which launched many pharmaceutical companies, tons of quinine are still purified for medicinal and beverage use. The quest for quinine synthesis pioneered early medicinal dyes, antibacterials, and other drugs. In a specialized Plasmodium lysosome for hemoglobin degradation, quinine binds heme, which inhibits heme crystallization to kill rapidly. Although quinine drug resistance was described 100 years ago, unlike chloroquinine or the antifolates that have been rendered ineffective by the spread of resistant mutants, quinine has only a few persistent, resistant parasites worldwide. The artemisinin drugs, superior to quinine for severe malaria, have greatly reduced the use of quinine as an antimalarial. Evidence for prolonged artemisinin parasite clearance times both renews the quest for rapidly parasiticidal drugs for severe malaria and possibly holds a place for quinine.

UR - http://www.scopus.com/inward/record.url?scp=85028293583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028293583&partnerID=8YFLogxK

U2 - 10.1007/978-3-0346-0480-2_3

DO - 10.1007/978-3-0346-0480-2_3

M3 - Chapter

AN - SCOPUS:84867018113

SN - 9783034604796

SP - 45

EP - 68

BT - Treatment and Prevention of Malaria

PB - Humana Press Inc.

ER -