CIN-ful cancers

Harith Rajagopalan; Christoph Lengauer

doi:10.1007/s00280-004-0889-8

CIN-ful cancers

Harith Rajagopalan, Christoph Lengauer

School of Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Aneuploidy has long been recognized to be a cardinal feature of many neoplasias. However, the role of aneuploidy in tumorigenesis continues to be a matter of debate. We believe that aneuploidy in cancers is the result of chromosomal instability, a process in which dividing cancer cells segregate their chromosomes with decreased fidelity. Here we discuss our definition of chromosomal instability, evidence for its causal role in tumor development, and suggestions regarding the mechanisms that initiate chromosomal instability in cancer cells.

Original language	English (US)
Journal	Cancer Chemotherapy and Pharmacology
Volume	54
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1007/s00280-004-0889-8
State	Published - Sep 2004

Keywords

Aneuploidy
Cancer
Chromosomal instability

ASJC Scopus subject areas

Cancer Research
Pharmacology
Oncology

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10.1007/s00280-004-0889-8

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AB - Aneuploidy has long been recognized to be a cardinal feature of many neoplasias. However, the role of aneuploidy in tumorigenesis continues to be a matter of debate. We believe that aneuploidy in cancers is the result of chromosomal instability, a process in which dividing cancer cells segregate their chromosomes with decreased fidelity. Here we discuss our definition of chromosomal instability, evidence for its causal role in tumor development, and suggestions regarding the mechanisms that initiate chromosomal instability in cancer cells.

KW - Aneuploidy

KW - Cancer

KW - Chromosomal instability

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CIN-ful cancers

Abstract

Keywords

ASJC Scopus subject areas

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