CIN-ful cancers

Harith Rajagopalan, Christoph Lengauer

Research output: Contribution to journalArticle

Abstract

Aneuploidy has long been recognized to be a cardinal feature of many neoplasias. However, the role of aneuploidy in tumorigenesis continues to be a matter of debate. We believe that aneuploidy in cancers is the result of chromosomal instability, a process in which dividing cancer cells segregate their chromosomes with decreased fidelity. Here we discuss our definition of chromosomal instability, evidence for its causal role in tumor development, and suggestions regarding the mechanisms that initiate chromosomal instability in cancer cells.

Original languageEnglish (US)
JournalCancer Chemotherapy and Pharmacology
Volume54
Issue numberSUPPL. 1
DOIs
StatePublished - Sep 2004

Fingerprint

Chromosomal Instability
Aneuploidy
Cells
Neoplasms
Chromosomes
Tumors
Carcinogenesis
Wolfiporia

Keywords

  • Aneuploidy
  • Cancer
  • Chromosomal instability

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology
  • Oncology

Cite this

CIN-ful cancers. / Rajagopalan, Harith; Lengauer, Christoph.

In: Cancer Chemotherapy and Pharmacology, Vol. 54, No. SUPPL. 1, 09.2004.

Research output: Contribution to journalArticle

Rajagopalan, H & Lengauer, C 2004, 'CIN-ful cancers', Cancer Chemotherapy and Pharmacology, vol. 54, no. SUPPL. 1. https://doi.org/10.1007/s00280-004-0889-8
Rajagopalan, Harith ; Lengauer, Christoph. / CIN-ful cancers. In: Cancer Chemotherapy and Pharmacology. 2004 ; Vol. 54, No. SUPPL. 1.
@article{b0f7e5a7b4004ecba02a112f90514966,
title = "CIN-ful cancers",
abstract = "Aneuploidy has long been recognized to be a cardinal feature of many neoplasias. However, the role of aneuploidy in tumorigenesis continues to be a matter of debate. We believe that aneuploidy in cancers is the result of chromosomal instability, a process in which dividing cancer cells segregate their chromosomes with decreased fidelity. Here we discuss our definition of chromosomal instability, evidence for its causal role in tumor development, and suggestions regarding the mechanisms that initiate chromosomal instability in cancer cells.",
keywords = "Aneuploidy, Cancer, Chromosomal instability",
author = "Harith Rajagopalan and Christoph Lengauer",
year = "2004",
month = "9",
doi = "10.1007/s00280-004-0889-8",
language = "English (US)",
volume = "54",
journal = "Cancer Chemotherapy and Pharmacology",
issn = "0344-5704",
publisher = "Springer Verlag",
number = "SUPPL. 1",

}

TY - JOUR

T1 - CIN-ful cancers

AU - Rajagopalan, Harith

AU - Lengauer, Christoph

PY - 2004/9

Y1 - 2004/9

N2 - Aneuploidy has long been recognized to be a cardinal feature of many neoplasias. However, the role of aneuploidy in tumorigenesis continues to be a matter of debate. We believe that aneuploidy in cancers is the result of chromosomal instability, a process in which dividing cancer cells segregate their chromosomes with decreased fidelity. Here we discuss our definition of chromosomal instability, evidence for its causal role in tumor development, and suggestions regarding the mechanisms that initiate chromosomal instability in cancer cells.

AB - Aneuploidy has long been recognized to be a cardinal feature of many neoplasias. However, the role of aneuploidy in tumorigenesis continues to be a matter of debate. We believe that aneuploidy in cancers is the result of chromosomal instability, a process in which dividing cancer cells segregate their chromosomes with decreased fidelity. Here we discuss our definition of chromosomal instability, evidence for its causal role in tumor development, and suggestions regarding the mechanisms that initiate chromosomal instability in cancer cells.

KW - Aneuploidy

KW - Cancer

KW - Chromosomal instability

UR - http://www.scopus.com/inward/record.url?scp=8744287401&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8744287401&partnerID=8YFLogxK

U2 - 10.1007/s00280-004-0889-8

DO - 10.1007/s00280-004-0889-8

M3 - Article

C2 - 15309517

AN - SCOPUS:8744287401

VL - 54

JO - Cancer Chemotherapy and Pharmacology

JF - Cancer Chemotherapy and Pharmacology

SN - 0344-5704

IS - SUPPL. 1

ER -