CIN-ful cancers

Harith Rajagopalan, Christoph Lengauer

Research output: Contribution to journalArticle

Abstract

Aneuploidy has long been recognized to be a cardinal feature of many neoplasias. However, the role of aneuploidy in tumorigenesis continues to be a matter of debate. We believe that aneuploidy in cancers is the result of chromosomal instability, a process in which dividing cancer cells segregate their chromosomes with decreased fidelity. Here we discuss our definition of chromosomal instability, evidence for its causal role in tumor development, and suggestions regarding the mechanisms that initiate chromosomal instability in cancer cells.

Original languageEnglish (US)
JournalCancer Chemotherapy and Pharmacology
Volume54
Issue numberSUPPL. 1
DOIs
StatePublished - Sep 2004

Keywords

  • Aneuploidy
  • Cancer
  • Chromosomal instability

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology
  • Oncology

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