Abstract
Aneuploidy has long been recognized to be a cardinal feature of many neoplasias. However, the role of aneuploidy in tumorigenesis continues to be a matter of debate. We believe that aneuploidy in cancers is the result of chromosomal instability, a process in which dividing cancer cells segregate their chromosomes with decreased fidelity. Here we discuss our definition of chromosomal instability, evidence for its causal role in tumor development, and suggestions regarding the mechanisms that initiate chromosomal instability in cancer cells.
| Original language | English (US) |
|---|---|
| Journal | Cancer Chemotherapy and Pharmacology |
| Volume | 54 |
| Issue number | SUPPL. 1 |
| DOIs | |
| State | Published - Sep 2004 |
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Keywords
- Aneuploidy
- Cancer
- Chromosomal instability
ASJC Scopus subject areas
- Cancer Research
- Pharmacology
- Oncology
Cite this
CIN-ful cancers. / Rajagopalan, Harith; Lengauer, Christoph.
In: Cancer Chemotherapy and Pharmacology, Vol. 54, No. SUPPL. 1, 09.2004.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CIN-ful cancers
AU - Rajagopalan, Harith
AU - Lengauer, Christoph
PY - 2004/9
Y1 - 2004/9
N2 - Aneuploidy has long been recognized to be a cardinal feature of many neoplasias. However, the role of aneuploidy in tumorigenesis continues to be a matter of debate. We believe that aneuploidy in cancers is the result of chromosomal instability, a process in which dividing cancer cells segregate their chromosomes with decreased fidelity. Here we discuss our definition of chromosomal instability, evidence for its causal role in tumor development, and suggestions regarding the mechanisms that initiate chromosomal instability in cancer cells.
AB - Aneuploidy has long been recognized to be a cardinal feature of many neoplasias. However, the role of aneuploidy in tumorigenesis continues to be a matter of debate. We believe that aneuploidy in cancers is the result of chromosomal instability, a process in which dividing cancer cells segregate their chromosomes with decreased fidelity. Here we discuss our definition of chromosomal instability, evidence for its causal role in tumor development, and suggestions regarding the mechanisms that initiate chromosomal instability in cancer cells.
KW - Aneuploidy
KW - Cancer
KW - Chromosomal instability
UR - http://www.scopus.com/inward/record.url?scp=8744287401&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=8744287401&partnerID=8YFLogxK
U2 - 10.1007/s00280-004-0889-8
DO - 10.1007/s00280-004-0889-8
M3 - Article
C2 - 15309517
AN - SCOPUS:8744287401
VL - 54
JO - Cancer Chemotherapy and Pharmacology
JF - Cancer Chemotherapy and Pharmacology
SN - 0344-5704
IS - SUPPL. 1
ER -