CIMPle origin for promoter hypermethylation in colorectal cancer?

Research output: Contribution to journalArticle

Abstract

The proposal that a distinct subset of colorectal cancers show a marked propensity for promoter CpG island DNA methylation and associated gene silencing has been hotly debated. A new study takes an unbiased approach and not only strongly concludes that a CpG island methylator phenotype exists, but also offers new markers to define a concept that could teach much about the origins of cancer.

Original languageEnglish (US)
Pages (from-to)738-740
Number of pages3
JournalNature Genetics
Volume38
Issue number7
DOIs
StatePublished - Jul 2006

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CpG Islands
Colorectal Neoplasms
Gene Silencing
DNA Methylation
Phenotype
Neoplasms

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

CIMPle origin for promoter hypermethylation in colorectal cancer? / Schuebel, Kornel; Chen, Wei; Baylin, Stephen B.

In: Nature Genetics, Vol. 38, No. 7, 07.2006, p. 738-740.

Research output: Contribution to journalArticle

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