Cigarette smoking and prostate cancer recurrence after prostatectomy

Corinne E. Joshu, Alison M. Mondul, Cari L. Meinhold, Elizabeth B. Humphreys, Misop Han, Patrick C. Walsh, Elizabeth A. Platz

Research output: Contribution to journalArticlepeer-review

Abstract

Toward the establishment of evidence-based recommendations for the prevention of prostate cancer recurrence after treatment, we examined the association between smoking and prostate cancer recurrence in a retrospective cohort study of 1416 men who underwent radical prostatectomy. Surgeries were performed by a single surgeon at Johns Hopkins Hospital between January 1, 1993, and March 31, 2006. Smoking status at 5 years before and 1 year after surgery was assessed by survey. Prostate cancer recurrence was defined as confirmed re-elevation of prostate-specific antigen levels, local recurrence, metastasis, or prostate cancer death. The cumulative incidence of recurrence was 34.3% among current smokers, 14.8% among former smokers, and 12.1% among never smokers, with a mean follow-up time of 7.3 years. Men who were current smokers at 1 year after surgery were more likely than never smokers to have disease recurrence after adjusting for pathological characteristics, including stage and grade (hazard ratio for recurrence = 2.31, 95% confidence interval = 1.05 to 5.10). This result suggests an association between cigarette smoking and risk of prostate cancer recurrence.

Original languageEnglish (US)
Pages (from-to)835-838
Number of pages4
JournalJournal of the National Cancer Institute
Volume103
Issue number10
DOIs
StatePublished - May 18 2011

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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