TY - JOUR
T1 - Cigarette smoking and malignant melanoma
T2 - A case-control study
AU - Kessides, Maria C.
AU - Wheless, Lee
AU - Hoffman-Bolton, Judith
AU - Clipp, Sandra
AU - Alani, Rhoda M.
AU - Alberg, Anthony J.
N1 - Funding Information:
Supported by RO1 CA105069 from the National Cancer Institute and a grant from the Doris Duke Charitable Foundation to Johns Hopkins University School of Medicine (Clinical Research Fellow Dr Kessides), and T32RR023258 from the National Center for Research Resources (Mr Wheless).
PY - 2011/1
Y1 - 2011/1
N2 - Background: Several previous studies have reported inverse associations between cigarette smoking and melanoma. Often these studies have not adjusted for ultraviolet (UV) exposure history, skin type, or number of blistering sunburns, which could confound the observed associations between cigarette smoking and melanoma. Objective: We sought to assess whether this reported inverse association persists after adjusting for UV exposure, skin type, and number of blistering sunburns. Methods: We conducted a population-based case-control study (82 patients with melanoma, 164 control subjects). Two control subjects were matched to each patient by age, sex, race, and skin type. Conditional logistic regression models were fit to assess the association between cigarette smoking history and melanoma, with additional adjustments for UV exposure and sunburns. Results: Compared with never smoking, both former (odds ratio 0.43, 95% confidence interval 0.18-1.04) and current (odds ratio 0.65, 95% confidence interval 0.19-2.24) smoking were inversely associated with melanoma, but the associations were not statistically significant. Limitations: The number of cutaneous nevi was not assessed in this study. In addition, the relatively small number of patients limits the statistical precision of the observed associations. Conclusions: After matching for age, sex, race, and skin type, and further adjusting for UV exposure and number of sunburns, cigarette smoking was not statistically significantly associated with melanoma risk, but the results were consistent with previous observations of an inverse association.
AB - Background: Several previous studies have reported inverse associations between cigarette smoking and melanoma. Often these studies have not adjusted for ultraviolet (UV) exposure history, skin type, or number of blistering sunburns, which could confound the observed associations between cigarette smoking and melanoma. Objective: We sought to assess whether this reported inverse association persists after adjusting for UV exposure, skin type, and number of blistering sunburns. Methods: We conducted a population-based case-control study (82 patients with melanoma, 164 control subjects). Two control subjects were matched to each patient by age, sex, race, and skin type. Conditional logistic regression models were fit to assess the association between cigarette smoking history and melanoma, with additional adjustments for UV exposure and sunburns. Results: Compared with never smoking, both former (odds ratio 0.43, 95% confidence interval 0.18-1.04) and current (odds ratio 0.65, 95% confidence interval 0.19-2.24) smoking were inversely associated with melanoma, but the associations were not statistically significant. Limitations: The number of cutaneous nevi was not assessed in this study. In addition, the relatively small number of patients limits the statistical precision of the observed associations. Conclusions: After matching for age, sex, race, and skin type, and further adjusting for UV exposure and number of sunburns, cigarette smoking was not statistically significantly associated with melanoma risk, but the results were consistent with previous observations of an inverse association.
KW - case-control study
KW - cigarette smoking
KW - epidemiology
KW - malignant melanoma
KW - skin cancer
KW - tobacco
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U2 - 10.1016/j.jaad.2010.01.041
DO - 10.1016/j.jaad.2010.01.041
M3 - Article
C2 - 20334951
AN - SCOPUS:78650306319
SN - 0190-9622
VL - 64
SP - 84
EP - 90
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 1
ER -