Cigarette smoking and cervical cancer: Part I: a meta-analysis.

Harry W. Haverkos, Guoxing Soon, Stacey L. Steckley, Wallace Pickworth

Research output: Contribution to journalReview articlepeer-review

Abstract

Cancer of the cervix is the third most common cancer among women worldwide and its etiology is not clearly understood. Human papillomavirus can be found in approximately 95% of cervical cancers, but it does not appear to be necessary or sufficient to induce malignancy. In 1977, Winkelstein suggested that cigarette smoking was a causative factor in the development of cervical cancer. We report a meta-analysis of cigarette smoking and cervical disease and conclude that the data support a role for cigarette smoking as a risk factor for cervical cancer. We propose a multifactorial hypothesis involving a virus-tar interaction as the etiology of cervical cancer.

Original languageEnglish (US)
Pages (from-to)67-77
Number of pages11
JournalBiomedicine and Pharmacotherapy
Volume57
Issue number2
DOIs
StatePublished - Mar 2003
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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