Abstract
Cancer of the cervix is the third most common cancer among women worldwide and its etiology is not clearly understood. Human papillomavirus can be found in approximately 95% of cervical cancers, but it does not appear to be necessary or sufficient to induce malignancy. In 1977, Winkelstein suggested that cigarette smoking was a causative factor in the development of cervical cancer. We report a meta-analysis of cigarette smoking and cervical disease and conclude that the data support a role for cigarette smoking as a risk factor for cervical cancer. We propose a multifactorial hypothesis involving a virus-tar interaction as the etiology of cervical cancer.
Original language | English (US) |
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Pages (from-to) | 67-77 |
Number of pages | 11 |
Journal | Biomedicine and Pharmacotherapy |
Volume | 57 |
Issue number | 2 |
DOIs | |
State | Published - Mar 2003 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology