Cigarette smokers self-administer intravenous nicotine

Jack E. Henningfield; Katsumasa Miyasato; Donald R. Jasinski

doi:10.1016/0091-3057(83)90099-0

Cigarette smokers self-administer intravenous nicotine

Jack E. Henningfield, Katsumasa Miyasato, Donald R. Jasinski

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Abstract

Human volunteers who smoked cigarettes were given the opportunity to press a lever that resulted in intravenous injections of saline or nicotine. Nicotine injections were taken in orderly patterns that were related to unit dose, whereas patterns of saline injections varied widely. Furthermore, the volunteers reported that nicotine produced subjective effects similar to those produced by administration of abused drugs such as morphine or cocaine.

Original language	English (US)
Pages (from-to)	887-890
Number of pages	4
Journal	Pharmacology Biochemistry and Behavior
Volume	19
Issue number	5
DOIs	https://doi.org/10.1016/0091-3057(83)90099-0
State	Published - 1983
Externally published	Yes

Keywords

Cigarette smokers
Drug abuse
Human studies
Nicotine
Self-administration

ASJC Scopus subject areas

Biochemistry
Behavioral Neuroscience
Pharmacology

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10.1016/0091-3057(83)90099-0

Cite this

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title = "Cigarette smokers self-administer intravenous nicotine",

abstract = "Human volunteers who smoked cigarettes were given the opportunity to press a lever that resulted in intravenous injections of saline or nicotine. Nicotine injections were taken in orderly patterns that were related to unit dose, whereas patterns of saline injections varied widely. Furthermore, the volunteers reported that nicotine produced subjective effects similar to those produced by administration of abused drugs such as morphine or cocaine.",

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author = "Henningfield, {Jack E.} and Katsumasa Miyasato and Jasinski, {Donald R.}",

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AU - Henningfield, Jack E.

AU - Miyasato, Katsumasa

AU - Jasinski, Donald R.

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Y1 - 1983

N2 - Human volunteers who smoked cigarettes were given the opportunity to press a lever that resulted in intravenous injections of saline or nicotine. Nicotine injections were taken in orderly patterns that were related to unit dose, whereas patterns of saline injections varied widely. Furthermore, the volunteers reported that nicotine produced subjective effects similar to those produced by administration of abused drugs such as morphine or cocaine.

AB - Human volunteers who smoked cigarettes were given the opportunity to press a lever that resulted in intravenous injections of saline or nicotine. Nicotine injections were taken in orderly patterns that were related to unit dose, whereas patterns of saline injections varied widely. Furthermore, the volunteers reported that nicotine produced subjective effects similar to those produced by administration of abused drugs such as morphine or cocaine.

KW - Cigarette smokers

KW - Drug abuse

KW - Human studies

KW - Nicotine

KW - Self-administration

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ER -

Cigarette smokers self-administer intravenous nicotine

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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