Cicatricial pemphigoid: Diagnosis and treatment

Dong Nguyen Quan Dong Nguyen, C. S. Foster

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


Cicatricial pemphigoid is a systemic autoimmune disease with both ocular and extraocular manifestations. Its effect on the eyes is characterized by chronic cicatrizing conjunctivitis and progressive conjunctival subepithelial fibrosis with resultant fornix foreshortening, symblepharon formation, trichiasis, meibomian, and lacrimal duct obstruction resulting in sicca syndrome, ocular surface keratinization, and eventually blindness. Extraocular manifestations include stricture formation of the esophagus, trachea, anus, or vagina. OCP is characterized by deposition of immunoreactants at the conjunctival basement membrane zone, initiating a type II hypersensitivity reaction. Demonstration of this deposition can be done using immunofluorescence or immunoperoxidase technique.

Original languageEnglish (US)
Pages (from-to)41-60
Number of pages20
JournalInternational ophthalmology clinics
Issue number1
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'Cicatricial pemphigoid: Diagnosis and treatment'. Together they form a unique fingerprint.

Cite this