Cicatricial pemphigoid: Diagnosis and treatment

Dong Nguyen Quan Dong Nguyen, C. S. Foster

Research output: Contribution to journalArticle

Abstract

Cicatricial pemphigoid is a systemic autoimmune disease with both ocular and extraocular manifestations. Its effect on the eyes is characterized by chronic cicatrizing conjunctivitis and progressive conjunctival subepithelial fibrosis with resultant fornix foreshortening, symblepharon formation, trichiasis, meibomian, and lacrimal duct obstruction resulting in sicca syndrome, ocular surface keratinization, and eventually blindness. Extraocular manifestations include stricture formation of the esophagus, trachea, anus, or vagina. OCP is characterized by deposition of immunoreactants at the conjunctival basement membrane zone, initiating a type II hypersensitivity reaction. Demonstration of this deposition can be done using immunofluorescence or immunoperoxidase technique.

Original languageEnglish (US)
Pages (from-to)41-60
Number of pages20
JournalInternational Ophthalmology Clinics
Volume36
Issue number1
DOIs
StatePublished - Dec 1996
Externally publishedYes

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Benign Mucous Membrane Pemphigoid
Lacrimal Duct Obstruction
Eye Manifestations
Trichiasis
Conjunctivitis
Sjogren's Syndrome
Anal Canal
Vagina
Blindness
Trachea
Immunoenzyme Techniques
Basement Membrane
Esophagus
Autoimmune Diseases
Fluorescent Antibody Technique
Hypersensitivity
Pathologic Constriction
Fibrosis
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Cicatricial pemphigoid : Diagnosis and treatment. / Quan Dong Nguyen, Dong Nguyen; Foster, C. S.

In: International Ophthalmology Clinics, Vol. 36, No. 1, 12.1996, p. 41-60.

Research output: Contribution to journalArticle

Quan Dong Nguyen, Dong Nguyen ; Foster, C. S. / Cicatricial pemphigoid : Diagnosis and treatment. In: International Ophthalmology Clinics. 1996 ; Vol. 36, No. 1. pp. 41-60.
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