Abstract
Cicatricial pemphigoid is a systemic autoimmune disease with both ocular and extraocular manifestations. Its effect on the eyes is characterized by chronic cicatrizing conjunctivitis and progressive conjunctival subepithelial fibrosis with resultant fornix foreshortening, symblepharon formation, trichiasis, meibomian, and lacrimal duct obstruction resulting in sicca syndrome, ocular surface keratinization, and eventually blindness. Extraocular manifestations include stricture formation of the esophagus, trachea, anus, or vagina. OCP is characterized by deposition of immunoreactants at the conjunctival basement membrane zone, initiating a type II hypersensitivity reaction. Demonstration of this deposition can be done using immunofluorescence or immunoperoxidase technique.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 41-60 |
| Number of pages | 20 |
| Journal | International Ophthalmology Clinics |
| Volume | 36 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Cicatricial pemphigoid : Diagnosis and treatment. / Quan Dong Nguyen, Dong Nguyen; Foster, C. S.
In: International Ophthalmology Clinics, Vol. 36, No. 1, 12.1996, p. 41-60.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cicatricial pemphigoid
T2 - Diagnosis and treatment
AU - Quan Dong Nguyen, Dong Nguyen
AU - Foster, C. S.
PY - 1996/12
Y1 - 1996/12
N2 - Cicatricial pemphigoid is a systemic autoimmune disease with both ocular and extraocular manifestations. Its effect on the eyes is characterized by chronic cicatrizing conjunctivitis and progressive conjunctival subepithelial fibrosis with resultant fornix foreshortening, symblepharon formation, trichiasis, meibomian, and lacrimal duct obstruction resulting in sicca syndrome, ocular surface keratinization, and eventually blindness. Extraocular manifestations include stricture formation of the esophagus, trachea, anus, or vagina. OCP is characterized by deposition of immunoreactants at the conjunctival basement membrane zone, initiating a type II hypersensitivity reaction. Demonstration of this deposition can be done using immunofluorescence or immunoperoxidase technique.
AB - Cicatricial pemphigoid is a systemic autoimmune disease with both ocular and extraocular manifestations. Its effect on the eyes is characterized by chronic cicatrizing conjunctivitis and progressive conjunctival subepithelial fibrosis with resultant fornix foreshortening, symblepharon formation, trichiasis, meibomian, and lacrimal duct obstruction resulting in sicca syndrome, ocular surface keratinization, and eventually blindness. Extraocular manifestations include stricture formation of the esophagus, trachea, anus, or vagina. OCP is characterized by deposition of immunoreactants at the conjunctival basement membrane zone, initiating a type II hypersensitivity reaction. Demonstration of this deposition can be done using immunofluorescence or immunoperoxidase technique.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029980451&partnerID=8YFLogxK
U2 - 10.1097/00004397-199603610-00007
DO - 10.1097/00004397-199603610-00007
M3 - Article
C2 - 8778068
AN - SCOPUS:0029980451
VL - 36
SP - 41
EP - 60
JO - International Ophthalmology Clinics
JF - International Ophthalmology Clinics
SN - 0020-8167
IS - 1
ER -