Chronic villitis in untreated neonatal alloimmune thrombocytopenia

An etiology for severe early intrauterine growth restriction and the effect of intravenous immunoglobulin therapy

Janyne Althaus, Edward G. Weir, Frederic B Askin, Thomas Stephen Kickler, Karin Blakemore

Research output: Contribution to journalArticle

Abstract

Objective: The objective of the study was to examine placental histopathology in intravenous immunoglobulin-treated and untreated neonatal alloimmune thrombocytopenia and correlate pathological findings with clinical outcomes. Study design: Placentas from 14 neonatal alloimmune thrombocytopenia-affected pregnancies were identified. Maternal antepartum treatment with intravenous immunoglobulin and pregnancy outcomes were abstracted from medical records. Placental histopathology and clinical outcomes were compared between intravenous immunoglobulin and no intravenous immunoglobulin treatment groups using Fisher's exact test. One subject, treated only after an intracranial hemorrhage (ICH) was diagnosed, was excluded from the analysis. P

Original languageEnglish (US)
Pages (from-to)1100-1104
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume193
Issue number3 SUPPL.
DOIs
StatePublished - Sep 2005

Fingerprint

Neonatal Alloimmune Thrombocytopenia
Passive Immunization
Intravenous Immunoglobulins
Growth
Intracranial Hemorrhages
Pregnancy Outcome
Placenta
Medical Records
Mothers
Pregnancy
Therapeutics

Keywords

  • Chronic villitis
  • Intrauterine growth restriction
  • Neonatal alloimmune thrombocytopenia

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

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abstract = "Objective: The objective of the study was to examine placental histopathology in intravenous immunoglobulin-treated and untreated neonatal alloimmune thrombocytopenia and correlate pathological findings with clinical outcomes. Study design: Placentas from 14 neonatal alloimmune thrombocytopenia-affected pregnancies were identified. Maternal antepartum treatment with intravenous immunoglobulin and pregnancy outcomes were abstracted from medical records. Placental histopathology and clinical outcomes were compared between intravenous immunoglobulin and no intravenous immunoglobulin treatment groups using Fisher's exact test. One subject, treated only after an intracranial hemorrhage (ICH) was diagnosed, was excluded from the analysis. P",
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AU - Blakemore, Karin

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AB - Objective: The objective of the study was to examine placental histopathology in intravenous immunoglobulin-treated and untreated neonatal alloimmune thrombocytopenia and correlate pathological findings with clinical outcomes. Study design: Placentas from 14 neonatal alloimmune thrombocytopenia-affected pregnancies were identified. Maternal antepartum treatment with intravenous immunoglobulin and pregnancy outcomes were abstracted from medical records. Placental histopathology and clinical outcomes were compared between intravenous immunoglobulin and no intravenous immunoglobulin treatment groups using Fisher's exact test. One subject, treated only after an intracranial hemorrhage (ICH) was diagnosed, was excluded from the analysis. P

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