Chronic T-lymphocyte activation in chronic renal failure: A study of hemodialysis, CAPD and pre-dialysis patients

R. J. Caruana, M. S. Leffell, S. A. Lobel, H. T. Campbell, P. L. Cheek

Research output: Contribution to journalArticle

Abstract

In this study we measured indices of T-lymphocyte activation in normal volunteers, chronic hemodialysis patients, CAPD patients and chronic renal failure patients not yet on dialysis. Serum IL-2 levels were elevated in patients compared to controls. Soluble IL-2 receptors were elevated in all three patient groups and were highest in CAPD patients. Clearance of IL-2 and soluble interleukin receptors was negligible in dialysis and renal failure patients. Hemodialysis patients had a significantly lower percentage of CD3-positive cells than all other groups. Hemodialysis with a variety of membrane/bath combinations did not significantly affect any of the parameters measured. This study provides some support for the hypothesis that chronic T-cell activation is present in renal failure.

Original languageEnglish (US)
Pages (from-to)93-98
Number of pages6
JournalInternational Journal of Artificial Organs
Volume15
Issue number2
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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    Caruana, R. J., Leffell, M. S., Lobel, S. A., Campbell, H. T., & Cheek, P. L. (1992). Chronic T-lymphocyte activation in chronic renal failure: A study of hemodialysis, CAPD and pre-dialysis patients. International Journal of Artificial Organs, 15(2), 93-98.