Chronic T-lymphocyte activation in chronic renal failure: A study of hemodialysis, CAPD and pre-dialysis patients

R. J. Caruana; M. S. Leffell; S. A. Lobel; H. T. Campbell; P. L. Cheek

doi:10.1177/039139889201500206

Chronic T-lymphocyte activation in chronic renal failure: A study of hemodialysis, CAPD and pre-dialysis patients

R. J. Caruana, M. S. Leffell, S. A. Lobel, H. T. Campbell, P. L. Cheek

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

In this study we measured indices of T-lymphocyte activation in normal volunteers, chronic hemodialysis patients, CAPD patients and chronic renal failure patients not yet on dialysis. Serum IL-2 levels were elevated in patients compared to controls. Soluble IL-2 receptors were elevated in all three patient groups and were highest in CAPD patients. Clearance of IL-2 and soluble interleukin receptors was negligible in dialysis and renal failure patients. Hemodialysis patients had a significantly lower percentage of CD3-positive cells than all other groups. Hemodialysis with a variety of membrane/bath combinations did not significantly affect any of the parameters measured. This study provides some support for the hypothesis that chronic T-cell activation is present in renal failure.

Original language	English (US)
Pages (from-to)	93-98
Number of pages	6
Journal	International Journal of Artificial Organs
Volume	15
Issue number	2
DOIs	https://doi.org/10.1177/039139889201500206
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomaterials
Biomedical Engineering

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AU - Lobel, S. A.

AU - Campbell, H. T.

AU - Cheek, P. L.

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Chronic T-lymphocyte activation in chronic renal failure: A study of hemodialysis, CAPD and pre-dialysis patients

Abstract

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