Chronic steroid-responsive encephalitis without autoantibodies to glutamate receptor GluR3

G. L. Krauss, M. L. Campbell, K. W. Roche, R. L. Huganir, E. Niedermeyer

Research output: Contribution to journalArticle

Abstract

Autoantibodies to GluR3, an AMPA glutamate receptor subtype, may be a cause of chronic unilateral encephalitis (Rasmussen's syndrome). We report a woman with chronic left hemisphere encephalitis whose partial seizures, aphasia, and motor weakness are highly responsive to intermittent steroids and cyclophosphamide. Her serum and CSF were negative for antibodies to GluR3 by both immunoblot and immunocytochemical analysis of cells transfected with GluR3 cDNA, indicating that separate immune-mediated processes may be involved in some cases of chronic encephalitis.

Original languageEnglish (US)
Pages (from-to)247-249
Number of pages3
JournalNeurology
Volume46
Issue number1
DOIs
StatePublished - Jan 1996

ASJC Scopus subject areas

  • Clinical Neurology

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