TY - CHAP
T1 - Chronic social stress
T2 - Effects on neuroendocrine function
AU - Scott, Karen A.
AU - Tamashiro, Kellie L.K.
AU - Sakai, Randall R.
N1 - Funding Information:
This research has been supported by NIH grants MH088230 (KAS), HD055030 (KLKT) and DK068273 (RRS).
PY - 2012
Y1 - 2012
N2 - This chapter discusses the importance of neuroethologically valid animal models of social stress, what information these models have produced, and how they may relate to the human condition. Interpersonal conflict, hostile work environments, perception of low socioeconomic status, or lack of social support can result in social stress exposure, which can negatively affect health. It is important to choose an appropriate species and model when testing hypotheses. Acknowledgement of the species' natural environment and behavioral repertoire has contributed greatly to our understanding of psychosocial stress. In humans, low socioeconomic status (SES) and lack of emotional support is associated with obesity, insulin resistance, type 2 diabetes, cardiovascular disease, and other characteristics of the metabolic syndrome. The relationship between social stress and obesity is complicated and somewhat paradoxical, since stress has been found to be associated with both decreased and increased food intake and body weight in animals. Social stress can have profound and paradoxical effects on the immune system, as the hypothalamic-pituitary-adrenal (HPA) axis and immune system have reciprocal interactions.
AB - This chapter discusses the importance of neuroethologically valid animal models of social stress, what information these models have produced, and how they may relate to the human condition. Interpersonal conflict, hostile work environments, perception of low socioeconomic status, or lack of social support can result in social stress exposure, which can negatively affect health. It is important to choose an appropriate species and model when testing hypotheses. Acknowledgement of the species' natural environment and behavioral repertoire has contributed greatly to our understanding of psychosocial stress. In humans, low socioeconomic status (SES) and lack of emotional support is associated with obesity, insulin resistance, type 2 diabetes, cardiovascular disease, and other characteristics of the metabolic syndrome. The relationship between social stress and obesity is complicated and somewhat paradoxical, since stress has been found to be associated with both decreased and increased food intake and body weight in animals. Social stress can have profound and paradoxical effects on the immune system, as the hypothalamic-pituitary-adrenal (HPA) axis and immune system have reciprocal interactions.
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U2 - 10.1016/B978-0-12-375097-6.10023-X
DO - 10.1016/B978-0-12-375097-6.10023-X
M3 - Chapter
AN - SCOPUS:84882823371
SN - 9780123750976
SP - 521
EP - 534
BT - Handbook of Neuroendocrinology
PB - Elsevier Inc.
ER -