Chronic Q fever in the United States

Petros C. Karakousis, Michele Trucksis, J. Stephen Dumler

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Infections due to Coxiella burnetii, the causative agent of Q fever, are uncommon in the United States. Cases of chronic Q fever are extremely rare and most often manifest as culture-negative endocarditis in patients with underlying valvular heart disease. We describe a 31-year-old farmer from West Virginia with a history of congenital heart disease and recurrent fevers for 14 months who was diagnosed with Q fever endocarditis based on an extremely high antibody titer against Coxiella burnetii phase I antigen. Despite treatment with doxycycline, he continued to have markedly elevated Coxiella burnetii phase I antibody titers for 10 years after the initial diagnosis. To our knowledge, this case represents the longest follow-up period for a patient with chronic Q fever in the United States. We review all cases of chronic Q fever reported in the United States and discuss important issues pertaining to epidemiology, diagnosis, and management of this disease.

Original languageEnglish (US)
Pages (from-to)2283-2287
Number of pages5
JournalJournal of clinical microbiology
Issue number6
StatePublished - Jun 2006
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)


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