Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities

Aliye Uc, Dana K. Andersen, Melena D. Bellin, Jason I. Bruce, Asbjørn M. Drewes, John F. Engelhardt, Christopher E. Forsmark, Markus M. Lerch, Mark E. Lowe, Brent A. Neuschwander-Tetri, Stephen J. O'Keefe, Tonya M. Palermo, Pankaj Jay Pasricha, Ashok K. Saluja, Vikesh Singh, Eva M. Szigethy, David C. Whitcomb, Dhiraj Yadav, Darwin L. Conwell

Research output: Contribution to journalArticle

Abstract

A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities in chronic pancreatitis (CP) and its sequelae. This conference marked the 20th year anniversary of the discovery of the cationic trypsinogen (PRSS1) gene mutation for hereditary pancreatitis. The event was held on July 27, 2016, and structured into 4 sessions: (1) pathophysiology, (2) exocrine complications, (3) endocrine complications, and (4) pain. The current state of knowledge was reviewed; many knowledge gaps and research needs were identified that require further investigation. Common themes included the need to design better tools to diagnose CP and its sequelae early and reliably, identify predisposing risk factors for disease progression, develop standardized protocols to distinguish type 3c diabetes mellitus from other types of diabetes, and design effective therapeutic strategies through novel cell culture technologies, animal models mimicking human disease, and pain management tools. Gene therapy and cystic fibrosis conductance regulator potentiators as possible treatments of CP were discussed. Importantly, the need for CP end points and intermediate targets for future drug trials was emphasized.

Original languageEnglish (US)
Pages (from-to)1365-1375
Number of pages11
JournalPancreas
Volume45
Issue number10
DOIs
StatePublished - Nov 1 2016

Fingerprint

Chronic Pancreatitis
Research
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Trypsinogen
Anniversaries and Special Events
Pain Management
Disease Management
Cystic Fibrosis
Causality
Genetic Therapy
Disease Progression
Diabetes Mellitus
Animal Models
Cell Culture Techniques
Technology
Education
Pain
Mutation
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Uc, A., Andersen, D. K., Bellin, M. D., Bruce, J. I., Drewes, A. M., Engelhardt, J. F., ... Conwell, D. L. (2016). Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities. Pancreas, 45(10), 1365-1375. https://doi.org/10.1097/MPA.0000000000000713

Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities. / Uc, Aliye; Andersen, Dana K.; Bellin, Melena D.; Bruce, Jason I.; Drewes, Asbjørn M.; Engelhardt, John F.; Forsmark, Christopher E.; Lerch, Markus M.; Lowe, Mark E.; Neuschwander-Tetri, Brent A.; O'Keefe, Stephen J.; Palermo, Tonya M.; Pasricha, Pankaj Jay; Saluja, Ashok K.; Singh, Vikesh; Szigethy, Eva M.; Whitcomb, David C.; Yadav, Dhiraj; Conwell, Darwin L.

In: Pancreas, Vol. 45, No. 10, 01.11.2016, p. 1365-1375.

Research output: Contribution to journalArticle

Uc, A, Andersen, DK, Bellin, MD, Bruce, JI, Drewes, AM, Engelhardt, JF, Forsmark, CE, Lerch, MM, Lowe, ME, Neuschwander-Tetri, BA, O'Keefe, SJ, Palermo, TM, Pasricha, PJ, Saluja, AK, Singh, V, Szigethy, EM, Whitcomb, DC, Yadav, D & Conwell, DL 2016, 'Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities', Pancreas, vol. 45, no. 10, pp. 1365-1375. https://doi.org/10.1097/MPA.0000000000000713
Uc A, Andersen DK, Bellin MD, Bruce JI, Drewes AM, Engelhardt JF et al. Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities. Pancreas. 2016 Nov 1;45(10):1365-1375. https://doi.org/10.1097/MPA.0000000000000713
Uc, Aliye ; Andersen, Dana K. ; Bellin, Melena D. ; Bruce, Jason I. ; Drewes, Asbjørn M. ; Engelhardt, John F. ; Forsmark, Christopher E. ; Lerch, Markus M. ; Lowe, Mark E. ; Neuschwander-Tetri, Brent A. ; O'Keefe, Stephen J. ; Palermo, Tonya M. ; Pasricha, Pankaj Jay ; Saluja, Ashok K. ; Singh, Vikesh ; Szigethy, Eva M. ; Whitcomb, David C. ; Yadav, Dhiraj ; Conwell, Darwin L. / Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities. In: Pancreas. 2016 ; Vol. 45, No. 10. pp. 1365-1375.
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