Abstract
INTRODUCTION. Chronic ocular graft versus host disease is one of the most common manifestations of chronic GVHD (cGVHD). It has been well recognized from the early allogeneic transplantation experience. Ocular GVHD affects approximately 60–80% of patients with cGVHD and can cause significant decrease in quality of life with high morbidity. The most common form of chronic ocular GVHD is dry eye syndrome (DES) with lacrimal gland dysfunction (reduced aqueous tear production) and keratoconjunctivitis sicca (KCS). Much of the early chronic ocular GVHD literature came from the experience at Johns Hopkins and elsewhere in the early 1980s. Since then, various studies and observations have been made in pathophysiology and in clinical experience in chronic ocular GVHD, in particular in treatment paradigm of organ-specific GVHD in the era of graft versus tumor considerations. National Institute of Health (NIH) Consensus Development Project on Criteria for Clinical Trials in Chronic Graft versus Host Disease published six papers, of which four papers are relevant to the chronic ocular GVHD. This chapter will describe in detail the clinical manifestations, diagnosis, pathophysiology, and management of chronic ocular GVHD and summarize the relevance of the NIH Consensus to ophthalmology. CLINICAL MANIFESTATIONS. Dry eye syndrome/KCS is the hallmark of chronic ocular GVHD. An earlier study noted that over 80% of patients with cGVHD experienced KCS. A later, multicenter retrospective study showed that 69% of patients who experienced KCS posttransplantation had cGVHD.
| Original language | English (US) |
|---|---|
| Title of host publication | Chronic Graft Versus Host Disease: Interdisciplinary Management |
| Publisher | Cambridge University Press |
| Pages | 199-206 |
| Number of pages | 8 |
| ISBN (Print) | 9780511576751, 9780521884235 |
| DOIs | |
| State | Published - Jan 1 2009 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Chronic ocular graft versus host disease. / Kim, Stella K.; Smith, Janine A.; Dunn, James P.
Chronic Graft Versus Host Disease: Interdisciplinary Management. Cambridge University Press, 2009. p. 199-206.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Chronic ocular graft versus host disease
AU - Kim, Stella K.
AU - Smith, Janine A.
AU - Dunn, James P.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - INTRODUCTION. Chronic ocular graft versus host disease is one of the most common manifestations of chronic GVHD (cGVHD). It has been well recognized from the early allogeneic transplantation experience. Ocular GVHD affects approximately 60–80% of patients with cGVHD and can cause significant decrease in quality of life with high morbidity. The most common form of chronic ocular GVHD is dry eye syndrome (DES) with lacrimal gland dysfunction (reduced aqueous tear production) and keratoconjunctivitis sicca (KCS). Much of the early chronic ocular GVHD literature came from the experience at Johns Hopkins and elsewhere in the early 1980s. Since then, various studies and observations have been made in pathophysiology and in clinical experience in chronic ocular GVHD, in particular in treatment paradigm of organ-specific GVHD in the era of graft versus tumor considerations. National Institute of Health (NIH) Consensus Development Project on Criteria for Clinical Trials in Chronic Graft versus Host Disease published six papers, of which four papers are relevant to the chronic ocular GVHD. This chapter will describe in detail the clinical manifestations, diagnosis, pathophysiology, and management of chronic ocular GVHD and summarize the relevance of the NIH Consensus to ophthalmology. CLINICAL MANIFESTATIONS. Dry eye syndrome/KCS is the hallmark of chronic ocular GVHD. An earlier study noted that over 80% of patients with cGVHD experienced KCS. A later, multicenter retrospective study showed that 69% of patients who experienced KCS posttransplantation had cGVHD.
AB - INTRODUCTION. Chronic ocular graft versus host disease is one of the most common manifestations of chronic GVHD (cGVHD). It has been well recognized from the early allogeneic transplantation experience. Ocular GVHD affects approximately 60–80% of patients with cGVHD and can cause significant decrease in quality of life with high morbidity. The most common form of chronic ocular GVHD is dry eye syndrome (DES) with lacrimal gland dysfunction (reduced aqueous tear production) and keratoconjunctivitis sicca (KCS). Much of the early chronic ocular GVHD literature came from the experience at Johns Hopkins and elsewhere in the early 1980s. Since then, various studies and observations have been made in pathophysiology and in clinical experience in chronic ocular GVHD, in particular in treatment paradigm of organ-specific GVHD in the era of graft versus tumor considerations. National Institute of Health (NIH) Consensus Development Project on Criteria for Clinical Trials in Chronic Graft versus Host Disease published six papers, of which four papers are relevant to the chronic ocular GVHD. This chapter will describe in detail the clinical manifestations, diagnosis, pathophysiology, and management of chronic ocular GVHD and summarize the relevance of the NIH Consensus to ophthalmology. CLINICAL MANIFESTATIONS. Dry eye syndrome/KCS is the hallmark of chronic ocular GVHD. An earlier study noted that over 80% of patients with cGVHD experienced KCS. A later, multicenter retrospective study showed that 69% of patients who experienced KCS posttransplantation had cGVHD.
UR - http://www.scopus.com/inward/record.url?scp=84857234802&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857234802&partnerID=8YFLogxK
U2 - 10.1017/CBO9780511576751.019
DO - 10.1017/CBO9780511576751.019
M3 - Chapter
AN - SCOPUS:84857234802
SN - 9780511576751
SN - 9780521884235
SP - 199
EP - 206
BT - Chronic Graft Versus Host Disease: Interdisciplinary Management
PB - Cambridge University Press
ER -