Chronic obstructive pulmonary disease and bronchopulmonary dysplasia: Common mechanisms but distinct manifestations?

Research output: Contribution to journalArticlepeer-review

Abstract

The complex disorders of chronic obstructive pulmonary disease (COPD) and bronchopulmonary dysplasia (BPD) are common, costly, and clinically burdensome. Both lung disorders develop after complex injurious triggers and can result in significant lung disease and disability. Similarities in their lung pathology and injury measures suggest common pathogenetic mechanisms. Evidence exists for both common molecular triggers and for injury-by-age interactions that may confer distinct end pathology. An emerging concept is that BPD may be a predisposing pathology for COPD development in late life. Future studies focusing on this provocative connection between BPD and COPD may translate into novel ameliorative and regenerative therapies for both disorders.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalPediatric, Allergy, Immunology, and Pulmonology
Volume24
Issue number2
DOIs
StatePublished - Jun 1 2011

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

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