Chronic obstructive pulmonary disease and association with mild cognitive impairment: The Mayo Clinic Study of Aging

Balwinder Singh, Ajay K. Parsaik, Michelle M. Mielke, Rosebud O. Roberts, Paul D. Scanlon, Yonas E. Geda, V. Shane Pankratz, Teresa Christianson, Barbara P. Yawn, Ronald C. Petersen

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Abstract

Objective: To investigate the association of chronic obstructive pulmonary disease (COPD) with mild cognitive impairment (MCI) and MCI subtype: amnestic MCI and nonamnestic MCI, in a populationbased study of elderly patients. Patients and Methods: Participants included 1927 individuals aged 70 to 89 years enrolled in the population-based Mayo Clinic Study of Aging. Participants were evaluated by using a nurse assessment, neurological evaluation, and neuropsychological testing, and the diagnosis of MCI was made by a consensus panel according to the standardized criteria. Chronic obstructive pulmonary disease was identified by the review of medical records. The study was conducted from October 1, 2004, through July 31, 2007. The associations of COPD and disease duration with MCI and its subtypes were evaluated by using logistic regression models adjusted for potential covariates. Results: Of 1927 participants, 288 had COPD (men vs women: 18% vs 12%; P

Original languageEnglish (US)
Pages (from-to)1222-1230
Number of pages9
JournalMayo Clinic Proceedings
Volume88
Issue number11
DOIs
StatePublished - 2013
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Singh, B., Parsaik, A. K., Mielke, M. M., Roberts, R. O., Scanlon, P. D., Geda, Y. E., Pankratz, V. S., Christianson, T., Yawn, B. P., & Petersen, R. C. (2013). Chronic obstructive pulmonary disease and association with mild cognitive impairment: The Mayo Clinic Study of Aging. Mayo Clinic Proceedings, 88(11), 1222-1230. https://doi.org/10.1016/j.mayocp.2013.08.012