Abstract
Benzene exposure is well demonstrated as a cause of acute myelogenous leukemia, but not of chronic myelogenous leukemia. Previous literature reviews based on case series and cohort studies have not shown an association. We have now conducted a literature search for case-control studies that examine the association between benzene exposure and chronic myelogenous leukemia. Six case-control studies have been found. These derive from occupational groups, cancer registries, and a clinical laboratory. Their exposure ascertainments are all based on job histories, job-exposure matricies, or industrial hygiene data. The odds ratios (ORs) for individual studies range from 0.73 to 1.2. The pooled OR is 1.003 with 95% confidence interval (CI) of 0.94-1.07 (p = 0.98) for both a fixed effects model and a random effects model. The case-control literature indicates that chronic myelogenous leukemia does not appear to be related to benzene exposure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 93-97 |
| Number of pages | 5 |
| Journal | Chemico-Biological Interactions |
| Volume | 182 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Dec 10 2009 |
| Externally published | Yes |
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Keywords
- Benzene exposure
- Case-control studies
- Chronic myelogenous leukemia (CML)
- Meta-analysis
ASJC Scopus subject areas
- Toxicology
Cite this
Chronic myelogenous leukemia and benzene exposure : A systematic review and meta-analysis of the case-control literature. / Lamm, Steven H.; Engel, Arnold; Joshi, Kiran P.; Byrd, Daniel M.; Chen, Rusan.
In: Chemico-Biological Interactions, Vol. 182, No. 2-3, 10.12.2009, p. 93-97.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic myelogenous leukemia and benzene exposure
T2 - A systematic review and meta-analysis of the case-control literature
AU - Lamm, Steven H.
AU - Engel, Arnold
AU - Joshi, Kiran P.
AU - Byrd, Daniel M.
AU - Chen, Rusan
PY - 2009/12/10
Y1 - 2009/12/10
N2 - Benzene exposure is well demonstrated as a cause of acute myelogenous leukemia, but not of chronic myelogenous leukemia. Previous literature reviews based on case series and cohort studies have not shown an association. We have now conducted a literature search for case-control studies that examine the association between benzene exposure and chronic myelogenous leukemia. Six case-control studies have been found. These derive from occupational groups, cancer registries, and a clinical laboratory. Their exposure ascertainments are all based on job histories, job-exposure matricies, or industrial hygiene data. The odds ratios (ORs) for individual studies range from 0.73 to 1.2. The pooled OR is 1.003 with 95% confidence interval (CI) of 0.94-1.07 (p = 0.98) for both a fixed effects model and a random effects model. The case-control literature indicates that chronic myelogenous leukemia does not appear to be related to benzene exposure.
AB - Benzene exposure is well demonstrated as a cause of acute myelogenous leukemia, but not of chronic myelogenous leukemia. Previous literature reviews based on case series and cohort studies have not shown an association. We have now conducted a literature search for case-control studies that examine the association between benzene exposure and chronic myelogenous leukemia. Six case-control studies have been found. These derive from occupational groups, cancer registries, and a clinical laboratory. Their exposure ascertainments are all based on job histories, job-exposure matricies, or industrial hygiene data. The odds ratios (ORs) for individual studies range from 0.73 to 1.2. The pooled OR is 1.003 with 95% confidence interval (CI) of 0.94-1.07 (p = 0.98) for both a fixed effects model and a random effects model. The case-control literature indicates that chronic myelogenous leukemia does not appear to be related to benzene exposure.
KW - Benzene exposure
KW - Case-control studies
KW - Chronic myelogenous leukemia (CML)
KW - Meta-analysis
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UR - http://www.scopus.com/inward/citedby.url?scp=70350135240&partnerID=8YFLogxK
U2 - 10.1016/j.cbi.2009.08.010
DO - 10.1016/j.cbi.2009.08.010
M3 - Article
C2 - 19695237
AN - SCOPUS:70350135240
VL - 182
SP - 93
EP - 97
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
SN - 0009-2797
IS - 2-3
ER -