Chronic myelogenous leukemia and benzene exposure: A systematic review and meta-analysis of the case-control literature

Steven H. Lamm, Arnold Engel, Kiran P. Joshi, Daniel M. Byrd, Rusan Chen

Research output: Contribution to journalArticle

Abstract

Benzene exposure is well demonstrated as a cause of acute myelogenous leukemia, but not of chronic myelogenous leukemia. Previous literature reviews based on case series and cohort studies have not shown an association. We have now conducted a literature search for case-control studies that examine the association between benzene exposure and chronic myelogenous leukemia. Six case-control studies have been found. These derive from occupational groups, cancer registries, and a clinical laboratory. Their exposure ascertainments are all based on job histories, job-exposure matricies, or industrial hygiene data. The odds ratios (ORs) for individual studies range from 0.73 to 1.2. The pooled OR is 1.003 with 95% confidence interval (CI) of 0.94-1.07 (p = 0.98) for both a fixed effects model and a random effects model. The case-control literature indicates that chronic myelogenous leukemia does not appear to be related to benzene exposure.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalChemico-Biological Interactions
Volume182
Issue number2-3
DOIs
StatePublished - Dec 10 2009
Externally publishedYes

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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Benzene
Meta-Analysis
Case-Control Studies
Odds Ratio
Industrial hygiene
Clinical laboratories
Occupational Groups
Occupational Health
Acute Myeloid Leukemia
Registries
Cohort Studies
Confidence Intervals
Neoplasms

Keywords

  • Benzene exposure
  • Case-control studies
  • Chronic myelogenous leukemia (CML)
  • Meta-analysis

ASJC Scopus subject areas

  • Toxicology

Cite this

Chronic myelogenous leukemia and benzene exposure : A systematic review and meta-analysis of the case-control literature. / Lamm, Steven H.; Engel, Arnold; Joshi, Kiran P.; Byrd, Daniel M.; Chen, Rusan.

In: Chemico-Biological Interactions, Vol. 182, No. 2-3, 10.12.2009, p. 93-97.

Research output: Contribution to journalArticle

Lamm, Steven H. ; Engel, Arnold ; Joshi, Kiran P. ; Byrd, Daniel M. ; Chen, Rusan. / Chronic myelogenous leukemia and benzene exposure : A systematic review and meta-analysis of the case-control literature. In: Chemico-Biological Interactions. 2009 ; Vol. 182, No. 2-3. pp. 93-97.
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