Abstract
Benzene exposure is well demonstrated as a cause of acute myelogenous leukemia, but not of chronic myelogenous leukemia. Previous literature reviews based on case series and cohort studies have not shown an association. We have now conducted a literature search for case-control studies that examine the association between benzene exposure and chronic myelogenous leukemia. Six case-control studies have been found. These derive from occupational groups, cancer registries, and a clinical laboratory. Their exposure ascertainments are all based on job histories, job-exposure matricies, or industrial hygiene data. The odds ratios (ORs) for individual studies range from 0.73 to 1.2. The pooled OR is 1.003 with 95% confidence interval (CI) of 0.94-1.07 (p = 0.98) for both a fixed effects model and a random effects model. The case-control literature indicates that chronic myelogenous leukemia does not appear to be related to benzene exposure.
Original language | English (US) |
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Pages (from-to) | 93-97 |
Number of pages | 5 |
Journal | Chemico-Biological Interactions |
Volume | 182 |
Issue number | 2-3 |
DOIs | |
State | Published - Dec 10 2009 |
Externally published | Yes |
Keywords
- Benzene exposure
- Case-control studies
- Chronic myelogenous leukemia (CML)
- Meta-analysis
ASJC Scopus subject areas
- Toxicology