Chronic myelogenous leukemia and benzene exposure: A systematic review and meta-analysis of the case-control literature

Steven H. Lamm, Arnold Engel, Kiran P. Joshi, Daniel M. Byrd, Rusan Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Benzene exposure is well demonstrated as a cause of acute myelogenous leukemia, but not of chronic myelogenous leukemia. Previous literature reviews based on case series and cohort studies have not shown an association. We have now conducted a literature search for case-control studies that examine the association between benzene exposure and chronic myelogenous leukemia. Six case-control studies have been found. These derive from occupational groups, cancer registries, and a clinical laboratory. Their exposure ascertainments are all based on job histories, job-exposure matricies, or industrial hygiene data. The odds ratios (ORs) for individual studies range from 0.73 to 1.2. The pooled OR is 1.003 with 95% confidence interval (CI) of 0.94-1.07 (p = 0.98) for both a fixed effects model and a random effects model. The case-control literature indicates that chronic myelogenous leukemia does not appear to be related to benzene exposure.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalChemico-Biological Interactions
Volume182
Issue number2-3
DOIs
StatePublished - Dec 10 2009
Externally publishedYes

Keywords

  • Benzene exposure
  • Case-control studies
  • Chronic myelogenous leukemia (CML)
  • Meta-analysis

ASJC Scopus subject areas

  • Toxicology

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