Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease

Sarah M. Rothman, Nathan Herdener, Kathryn A. Frankola, Mohamed R. Mughal, Mark P. Mattson

Research output: Contribution to journalArticle

Abstract

Age-associated dysregulation of sleep can be worsened by Alzheimer's disease (AD). AD and sleep restriction both impair cognition, yet it is unknown if mild chronic sleep restriction modifies the proteopathic processes involved in AD. The goal of this work was to test the hypothesis that sleep restriction worsens memory impairments, and amyloid β-peptide (Aβ) and pTau accumulations in the brain in a mouse model of AD, with a focus on a role for circulating glucocorticoids (GC). Male 3xTgAD mice were subjected to sleep restriction (SR) for 6 h/day for 6 weeks using the modified multiple platform technique, and behavioral (Morris water maze, fear conditioning, open field) and biochemical (immunoblot) outcomes were compared to mice undergoing daily cage transfers (large cage control; LCC) as well as control mice that remained in their home cage (control; CTL). At one week, both LCC and SR mice displayed significant elevations in plasma corticosterone compared to CTL (p

Original languageEnglish (US)
Pages (from-to)200-208
Number of pages9
JournalBrain Research
Volume1529
DOIs
StatePublished - Sep 5 2013
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid
  • Fear conditioning
  • Glucocorticoids
  • Morris water maze
  • Sleep restriction

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology
  • Medicine(all)

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