Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease

Sarah M. Rothman, Nathan Herdener, Kathryn A. Frankola, Mohamed R. Mughal, Mark P. Mattson

Research output: Contribution to journalArticle

Abstract

Age-associated dysregulation of sleep can be worsened by Alzheimer's disease (AD). AD and sleep restriction both impair cognition, yet it is unknown if mild chronic sleep restriction modifies the proteopathic processes involved in AD. The goal of this work was to test the hypothesis that sleep restriction worsens memory impairments, and amyloid β-peptide (Aβ) and pTau accumulations in the brain in a mouse model of AD, with a focus on a role for circulating glucocorticoids (GC). Male 3xTgAD mice were subjected to sleep restriction (SR) for 6 h/day for 6 weeks using the modified multiple platform technique, and behavioral (Morris water maze, fear conditioning, open field) and biochemical (immunoblot) outcomes were compared to mice undergoing daily cage transfers (large cage control; LCC) as well as control mice that remained in their home cage (control; CTL). At one week, both LCC and SR mice displayed significant elevations in plasma corticosterone compared to CTL (p

Original languageEnglish (US)
Pages (from-to)200-208
Number of pages9
JournalBrain Research
Volume1529
DOIs
StatePublished - Sep 5 2013
Externally publishedYes

Fingerprint

Alzheimer Disease
Sleep
Corticosterone
Amyloid
Cognition
Glucocorticoids
Fear
Water
Brain

Keywords

  • Alzheimer's disease
  • Amyloid
  • Fear conditioning
  • Glucocorticoids
  • Morris water maze
  • Sleep restriction

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease. / Rothman, Sarah M.; Herdener, Nathan; Frankola, Kathryn A.; Mughal, Mohamed R.; Mattson, Mark P.

In: Brain Research, Vol. 1529, 05.09.2013, p. 200-208.

Research output: Contribution to journalArticle

Rothman, Sarah M. ; Herdener, Nathan ; Frankola, Kathryn A. ; Mughal, Mohamed R. ; Mattson, Mark P. / Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease. In: Brain Research. 2013 ; Vol. 1529. pp. 200-208.
@article{834e2c006a0449aba7f50e16efb210ce,
title = "Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease",
abstract = "Age-associated dysregulation of sleep can be worsened by Alzheimer's disease (AD). AD and sleep restriction both impair cognition, yet it is unknown if mild chronic sleep restriction modifies the proteopathic processes involved in AD. The goal of this work was to test the hypothesis that sleep restriction worsens memory impairments, and amyloid β-peptide (Aβ) and pTau accumulations in the brain in a mouse model of AD, with a focus on a role for circulating glucocorticoids (GC). Male 3xTgAD mice were subjected to sleep restriction (SR) for 6 h/day for 6 weeks using the modified multiple platform technique, and behavioral (Morris water maze, fear conditioning, open field) and biochemical (immunoblot) outcomes were compared to mice undergoing daily cage transfers (large cage control; LCC) as well as control mice that remained in their home cage (control; CTL). At one week, both LCC and SR mice displayed significant elevations in plasma corticosterone compared to CTL (p",
keywords = "Alzheimer's disease, Amyloid, Fear conditioning, Glucocorticoids, Morris water maze, Sleep restriction",
author = "Rothman, {Sarah M.} and Nathan Herdener and Frankola, {Kathryn A.} and Mughal, {Mohamed R.} and Mattson, {Mark P.}",
year = "2013",
month = "9",
day = "5",
doi = "10.1016/j.brainres.2013.07.010",
language = "English (US)",
volume = "1529",
pages = "200--208",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",

}

TY - JOUR

T1 - Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease

AU - Rothman, Sarah M.

AU - Herdener, Nathan

AU - Frankola, Kathryn A.

AU - Mughal, Mohamed R.

AU - Mattson, Mark P.

PY - 2013/9/5

Y1 - 2013/9/5

N2 - Age-associated dysregulation of sleep can be worsened by Alzheimer's disease (AD). AD and sleep restriction both impair cognition, yet it is unknown if mild chronic sleep restriction modifies the proteopathic processes involved in AD. The goal of this work was to test the hypothesis that sleep restriction worsens memory impairments, and amyloid β-peptide (Aβ) and pTau accumulations in the brain in a mouse model of AD, with a focus on a role for circulating glucocorticoids (GC). Male 3xTgAD mice were subjected to sleep restriction (SR) for 6 h/day for 6 weeks using the modified multiple platform technique, and behavioral (Morris water maze, fear conditioning, open field) and biochemical (immunoblot) outcomes were compared to mice undergoing daily cage transfers (large cage control; LCC) as well as control mice that remained in their home cage (control; CTL). At one week, both LCC and SR mice displayed significant elevations in plasma corticosterone compared to CTL (p

AB - Age-associated dysregulation of sleep can be worsened by Alzheimer's disease (AD). AD and sleep restriction both impair cognition, yet it is unknown if mild chronic sleep restriction modifies the proteopathic processes involved in AD. The goal of this work was to test the hypothesis that sleep restriction worsens memory impairments, and amyloid β-peptide (Aβ) and pTau accumulations in the brain in a mouse model of AD, with a focus on a role for circulating glucocorticoids (GC). Male 3xTgAD mice were subjected to sleep restriction (SR) for 6 h/day for 6 weeks using the modified multiple platform technique, and behavioral (Morris water maze, fear conditioning, open field) and biochemical (immunoblot) outcomes were compared to mice undergoing daily cage transfers (large cage control; LCC) as well as control mice that remained in their home cage (control; CTL). At one week, both LCC and SR mice displayed significant elevations in plasma corticosterone compared to CTL (p

KW - Alzheimer's disease

KW - Amyloid

KW - Fear conditioning

KW - Glucocorticoids

KW - Morris water maze

KW - Sleep restriction

UR - http://www.scopus.com/inward/record.url?scp=84882580016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882580016&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2013.07.010

DO - 10.1016/j.brainres.2013.07.010

M3 - Article

C2 - 23856323

AN - SCOPUS:84882580016

VL - 1529

SP - 200

EP - 208

JO - Brain Research

JF - Brain Research

SN - 0006-8993

ER -