Chronic lung allograft dysfunction

Oxygen-enhanced T1-mapping MR imaging of the lung

Julius Renne, Peer Lauermann, Jan B. Hinrichs, Christian Schönfeld, Sajoscha Sorrentino, Marcel Gutberlet, Peter Jakob, Axel Haverich, Gregor Warnecke, Tobias Welte, Frank K. Wacker, Jens Gottlieb, Jens Vogel-Claussen

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate oxygen-enhanced T1-mapping magnetic resonance (MR) imaging of the lungs for detection of chronic lung allograft dysfunction (CLAD) in patients who have undergone double lung transplantation. Materials and Methods: The local ethics committee approved this study. Seventysix recipients of double lung allografts who underwent MR imaging of the lungs during an outpatient visit between 2011 and 2013 were included in this study after they provided written informed consent. Patients were classified as having CLAD on the basis of spirometric results and were divided into three groups: no CLAD (bronchiolitis obliterans syndrome level 0 [BOS 0]), early CLAD (BOS 0p), and late-stage CLAD (BOS 1-3). Coronal T1 maps of the lungs were acquired with the patient breathing room air and 100% oxygen by using an inversion-recovery snapshot fast low-angle shot sequence at 1.5 T. The median and interquartile range of T1 values at room air and at 100% oxygen and the oxygen transfer function were calculated. Statistical analysis was performed with analysis of variance and the Tukey honestly significant difference test or the Kruskal-Wallis test and the Mann-Whitney U test (α = 0.05). Bonferroni correction was applied for multiple comparisons. Results: The oxygen transfer function was significantly lower in patients in the BOS 0p (P = .025) and BOS 1-3 groups (P = .003) than it was in the patients with BOS 0. Absolute T1 values (room air, P = .66; 100% oxygen, P = .67) did not differ significantly among the groups. The heterogeneity of T1 values, measured by using the interquartile range, showed a strong trend toward higher values in patients with BOS (room air, P = .06; 100% oxygen, P = .08). Conclusion: Oxygen transfer function may serve as an early marker for detection of CLAD.

Original languageEnglish (US)
Pages (from-to)266-273
Number of pages8
JournalRadiology
Volume276
Issue number1
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

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Allografts
Magnetic Resonance Imaging
Oxygen
Lung
Air
Bronchiolitis Obliterans
Patients' Rooms
Ethics Committees
Lung Transplantation
Nonparametric Statistics
Informed Consent
Analysis of Variance
Respiration
Outpatients

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Renne, J., Lauermann, P., Hinrichs, J. B., Schönfeld, C., Sorrentino, S., Gutberlet, M., ... Vogel-Claussen, J. (2015). Chronic lung allograft dysfunction: Oxygen-enhanced T1-mapping MR imaging of the lung. Radiology, 276(1), 266-273. https://doi.org/10.1148/radiol.15141486

Chronic lung allograft dysfunction : Oxygen-enhanced T1-mapping MR imaging of the lung. / Renne, Julius; Lauermann, Peer; Hinrichs, Jan B.; Schönfeld, Christian; Sorrentino, Sajoscha; Gutberlet, Marcel; Jakob, Peter; Haverich, Axel; Warnecke, Gregor; Welte, Tobias; Wacker, Frank K.; Gottlieb, Jens; Vogel-Claussen, Jens.

In: Radiology, Vol. 276, No. 1, 01.07.2015, p. 266-273.

Research output: Contribution to journalArticle

Renne, J, Lauermann, P, Hinrichs, JB, Schönfeld, C, Sorrentino, S, Gutberlet, M, Jakob, P, Haverich, A, Warnecke, G, Welte, T, Wacker, FK, Gottlieb, J & Vogel-Claussen, J 2015, 'Chronic lung allograft dysfunction: Oxygen-enhanced T1-mapping MR imaging of the lung', Radiology, vol. 276, no. 1, pp. 266-273. https://doi.org/10.1148/radiol.15141486
Renne J, Lauermann P, Hinrichs JB, Schönfeld C, Sorrentino S, Gutberlet M et al. Chronic lung allograft dysfunction: Oxygen-enhanced T1-mapping MR imaging of the lung. Radiology. 2015 Jul 1;276(1):266-273. https://doi.org/10.1148/radiol.15141486
Renne, Julius ; Lauermann, Peer ; Hinrichs, Jan B. ; Schönfeld, Christian ; Sorrentino, Sajoscha ; Gutberlet, Marcel ; Jakob, Peter ; Haverich, Axel ; Warnecke, Gregor ; Welte, Tobias ; Wacker, Frank K. ; Gottlieb, Jens ; Vogel-Claussen, Jens. / Chronic lung allograft dysfunction : Oxygen-enhanced T1-mapping MR imaging of the lung. In: Radiology. 2015 ; Vol. 276, No. 1. pp. 266-273.
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abstract = "Purpose: To evaluate oxygen-enhanced T1-mapping magnetic resonance (MR) imaging of the lungs for detection of chronic lung allograft dysfunction (CLAD) in patients who have undergone double lung transplantation. Materials and Methods: The local ethics committee approved this study. Seventysix recipients of double lung allografts who underwent MR imaging of the lungs during an outpatient visit between 2011 and 2013 were included in this study after they provided written informed consent. Patients were classified as having CLAD on the basis of spirometric results and were divided into three groups: no CLAD (bronchiolitis obliterans syndrome level 0 [BOS 0]), early CLAD (BOS 0p), and late-stage CLAD (BOS 1-3). Coronal T1 maps of the lungs were acquired with the patient breathing room air and 100{\%} oxygen by using an inversion-recovery snapshot fast low-angle shot sequence at 1.5 T. The median and interquartile range of T1 values at room air and at 100{\%} oxygen and the oxygen transfer function were calculated. Statistical analysis was performed with analysis of variance and the Tukey honestly significant difference test or the Kruskal-Wallis test and the Mann-Whitney U test (α = 0.05). Bonferroni correction was applied for multiple comparisons. Results: The oxygen transfer function was significantly lower in patients in the BOS 0p (P = .025) and BOS 1-3 groups (P = .003) than it was in the patients with BOS 0. Absolute T1 values (room air, P = .66; 100{\%} oxygen, P = .67) did not differ significantly among the groups. The heterogeneity of T1 values, measured by using the interquartile range, showed a strong trend toward higher values in patients with BOS (room air, P = .06; 100{\%} oxygen, P = .08). Conclusion: Oxygen transfer function may serve as an early marker for detection of CLAD.",
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AU - Hinrichs, Jan B.

AU - Schönfeld, Christian

AU - Sorrentino, Sajoscha

AU - Gutberlet, Marcel

AU - Jakob, Peter

AU - Haverich, Axel

AU - Warnecke, Gregor

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