TY - JOUR
T1 - Chronic low intakes of vitamin A-rich foods in households with xerophthalmic children
T2 - A case-control study in Nepal
AU - Shankar, Anita V.
AU - West, Keith P.
AU - Gittelsohn, Joel
AU - Katz, Joanne
AU - Pradhan, Rajendra
PY - 1996/8
Y1 - 1996/8
N2 - Dietary patterns in 81 rural Nepali households with a 1-6 y-old child with a history of xerophthalmia were compared with dietary patterns of 81 households with an age matched nonxerophthalmic control subject. Weekly food- frequency questionnaires were collected from case and control 'focus' children, a younger sibling (if present), and the household 1-2 y after recruitment and treatment of cases. Control households and children were more likely than case households and children to consume vitamin A-rich foods during the monsoon (July-September) and major rice harvesting (October- December) seasons. Cases were less likely to consume preformed vitamin A- rich foods throughout the year [odds ratio (OR) = 1.2-4.5] with the strongest differences observed from October to December (OR = 2.0-4.2). Dietary risks were generally shared by younger siblings of cases, suggesting that infrequent intake of β-carotene and preformed vitamin-A rich foods begins early in life and clusters among siblings within households, a pattern that is consistent with their higher risk of xerophthalmia and mortality. In developing countries where vitamin A deficiency is endemic, dietary counseling for children with xerophthalmia should be extended to their younger siblings. Moreover, dietary intake of preformed vitamin A may be as, or more, important as carotenoid-containing food consumption in protecting children and other members of households from vitamin A deficiency.
AB - Dietary patterns in 81 rural Nepali households with a 1-6 y-old child with a history of xerophthalmia were compared with dietary patterns of 81 households with an age matched nonxerophthalmic control subject. Weekly food- frequency questionnaires were collected from case and control 'focus' children, a younger sibling (if present), and the household 1-2 y after recruitment and treatment of cases. Control households and children were more likely than case households and children to consume vitamin A-rich foods during the monsoon (July-September) and major rice harvesting (October- December) seasons. Cases were less likely to consume preformed vitamin A- rich foods throughout the year [odds ratio (OR) = 1.2-4.5] with the strongest differences observed from October to December (OR = 2.0-4.2). Dietary risks were generally shared by younger siblings of cases, suggesting that infrequent intake of β-carotene and preformed vitamin-A rich foods begins early in life and clusters among siblings within households, a pattern that is consistent with their higher risk of xerophthalmia and mortality. In developing countries where vitamin A deficiency is endemic, dietary counseling for children with xerophthalmia should be extended to their younger siblings. Moreover, dietary intake of preformed vitamin A may be as, or more, important as carotenoid-containing food consumption in protecting children and other members of households from vitamin A deficiency.
KW - Dietary assessment
KW - case-control studies
KW - child feeding
KW - seasonality
KW - vitamin A deficiency
KW - xerophthalmia
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U2 - 10.1093/ajcn/64.2.242
DO - 10.1093/ajcn/64.2.242
M3 - Article
C2 - 8694027
AN - SCOPUS:0030036827
SN - 0002-9165
VL - 64
SP - 242
EP - 248
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 2
ER -