Chronic lithium treatment prevents the dexamethasone-induced increase of brain polymine metabolizing enzymes

Gad M. Gilad, Varda H. Gilad, Richard Jed Wyatt, Robert A. Casero

Research output: Contribution to journalArticle

Abstract

The paper describes the effects of various regimens of lithium chloride treatment on dexamethasone-induced increases in brain polyamine metabolizing enzymes. In contrast to peripheral tissues where acute lithium treatment suppresses the increase in ornithine decarboxylase activity, in the brain only chronic treatment was effective in preventing this increase and also the increases in the activities of S-adenosylmethionine decarboxylase and spermidine/spermine N1-acetyltransferase. This findings indicate a novel brain target for lithium's action and in turn provide new avenues for exploring polyamine function in the brain.

Original languageEnglish (US)
Pages (from-to)PL149-PL154
JournalLife Sciences
Volume50
Issue number18
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Chronic lithium treatment prevents the dexamethasone-induced increase of brain polymine metabolizing enzymes'. Together they form a unique fingerprint.

  • Cite this