Abstract
The morphologic effects on the retina resulting from chronic lead exposure were assessed in neonatal rats. Newborn rats nursed from dams were given a low (0.115%) or a high (4.5%) concentration of lead in their diet. At day 21 the pups were weaned to the mother’s diet. The retinas of the pups were studied by electron microscopy at various ages up to day 60. High and low lead concentrations produced necrosis of photoreceptor cells and cells of the inner nuclear layer. The high lead concentration, in addition, was associated with swelling of endothelial cells of the retinal vessels and narrowing of the lumen. Increased permeability of the retinal vessels and pigment epithelium to horseradish peroxidase was also observed under the high-dose condition. The authors conclude that lead can produce direct neuronal damage and, at high doses, produces retinal vascular lesions and alteration of the blood-retinal barrier.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 175-187 |
| Number of pages | 13 |
| Journal | Journal of Neuropathology and Experimental Neurology |
| Volume | 43 |
| Issue number | 2 |
| State | Published - 1984 |
| Externally published | Yes |
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Keywords
- Horseradish peroxidase
- Lead
- Neonatal
- Rat
- Retina
ASJC Scopus subject areas
- Clinical Neurology
- Pathology and Forensic Medicine
- Cellular and Molecular Neuroscience
- Neurology
- Neuroscience(all)
Cite this
Chronic lead administration in neonatal rats : Electron microscopy of the retina. / Santos-Anderson, Rebecca M.; Tso, Mark; Valdes, James J.; Annau, Zoltan.
In: Journal of Neuropathology and Experimental Neurology, Vol. 43, No. 2, 1984, p. 175-187.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic lead administration in neonatal rats
T2 - Electron microscopy of the retina
AU - Santos-Anderson, Rebecca M.
AU - Tso, Mark
AU - Valdes, James J.
AU - Annau, Zoltan
PY - 1984
Y1 - 1984
N2 - The morphologic effects on the retina resulting from chronic lead exposure were assessed in neonatal rats. Newborn rats nursed from dams were given a low (0.115%) or a high (4.5%) concentration of lead in their diet. At day 21 the pups were weaned to the mother’s diet. The retinas of the pups were studied by electron microscopy at various ages up to day 60. High and low lead concentrations produced necrosis of photoreceptor cells and cells of the inner nuclear layer. The high lead concentration, in addition, was associated with swelling of endothelial cells of the retinal vessels and narrowing of the lumen. Increased permeability of the retinal vessels and pigment epithelium to horseradish peroxidase was also observed under the high-dose condition. The authors conclude that lead can produce direct neuronal damage and, at high doses, produces retinal vascular lesions and alteration of the blood-retinal barrier.
AB - The morphologic effects on the retina resulting from chronic lead exposure were assessed in neonatal rats. Newborn rats nursed from dams were given a low (0.115%) or a high (4.5%) concentration of lead in their diet. At day 21 the pups were weaned to the mother’s diet. The retinas of the pups were studied by electron microscopy at various ages up to day 60. High and low lead concentrations produced necrosis of photoreceptor cells and cells of the inner nuclear layer. The high lead concentration, in addition, was associated with swelling of endothelial cells of the retinal vessels and narrowing of the lumen. Increased permeability of the retinal vessels and pigment epithelium to horseradish peroxidase was also observed under the high-dose condition. The authors conclude that lead can produce direct neuronal damage and, at high doses, produces retinal vascular lesions and alteration of the blood-retinal barrier.
KW - Horseradish peroxidase
KW - Lead
KW - Neonatal
KW - Rat
KW - Retina
UR - http://www.scopus.com/inward/record.url?scp=0021350090&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021350090&partnerID=8YFLogxK
M3 - Article
C2 - 6608578
AN - SCOPUS:0021350090
VL - 43
SP - 175
EP - 187
JO - American Journal of Psychotherapy
JF - American Journal of Psychotherapy
SN - 0002-9564
IS - 2
ER -