Chronic kidney disease and cognitive function in older adults: Findings from the chronic renal insufficiency cohort cognitive study

Kristine Yaffe, Lynn Ackerson, Manjula Kurella Tamura, Patti Le Blanc, John W. Kusek, Ashwini R. Sehgal, Debbie Cohen, Cheryl Anderson, Lawrence Appel, Karen Desalvo, Akinlolu Ojo, Stephen Seliger, Nancy Robinson, Gail Makos, Alan S. Go

Research output: Contribution to journalArticle

Abstract

Objectives: To investigate cognitive impairment in older, ethnically diverse individuals with a broad range of kidney function, to evaluate a spectrum of cognitive domains, and to determine whether the relationship between chronic kidney disease (CKD) and cognitive function is independent of demographic and clinical factors. Design: Cross-sectional. Setting: Chronic Renal Insufficiency Cohort Study. Participants: Eight hundred twenty-five adults aged 55 and older with CKD. Measurements: Estimated glomerular filtration rate (eGFR, mL/min per 1.73 m2) was estimated using the four-variable Modification of Diet in Renal Disease equation. Cognitive scores on six cognitive tests were compared across eGFR strata using linear regression; multivariable logistic regression was used to examine level of CKD and clinically significant cognitive impairment (score ≤1 standard deviations from the mean). Results: Mean age of the participants was 64.9, 50.4% were male, and 44.5% were black. After multivariable adjustment, participants with lower eGFR had lower cognitive scores on most cognitive domains (P

Original languageEnglish (US)
Pages (from-to)338-345
Number of pages8
JournalJournal of the American Geriatrics Society
Volume58
Issue number2
DOIs
StatePublished - Feb 2010

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Keywords

  • Chronic kidney disease
  • Cognitive function
  • Cognitive impairment

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Yaffe, K., Ackerson, L., Tamura, M. K., Le Blanc, P., Kusek, J. W., Sehgal, A. R., Cohen, D., Anderson, C., Appel, L., Desalvo, K., Ojo, A., Seliger, S., Robinson, N., Makos, G., & Go, A. S. (2010). Chronic kidney disease and cognitive function in older adults: Findings from the chronic renal insufficiency cohort cognitive study. Journal of the American Geriatrics Society, 58(2), 338-345. https://doi.org/10.1111/j.1532-5415.2009.02670.x